Rapid determination of enantiomeric excess via NMR spectroscopy: a research-informed experiment

Research output: Contribution to journalArticlepeer-review


  • Eric V. Anslyn
  • William D. G. Brittain
  • Steven D. Bull
  • Brette M. Chapin
  • Cécile S. Le Duff
  • Stephanie Lim
  • Jennifer A. C. Lloyd
  • Charles V. Manville
  • Daniel T. Payne

Colleges, School and Institutes


An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.


Original languageEnglish
Pages (from-to)79-84
Number of pages5
JournalJournal of Chemical Education
Issue number1
Early online date30 Sep 2016
Publication statusPublished - Jan 2017


  • Analytical Chemistry, Chirality/Optical Activity, Hands-On Learning/Manipulatives, Computer-Based Learning