Rapid cycling as a feature of bipolar disorder and comorbid migraine

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Rapid cycling as a feature of bipolar disorder and comorbid migraine. / Gordon-smith, K.; Forty, L.; Chan, C.; Knott, S.; Jones, I.; Craddock, N.; Jones, Lisa.

In: Journal of Affective Disorders, Vol. 175, 01.04.2015, p. 320-324.

Research output: Contribution to journalArticlepeer-review

Harvard

Gordon-smith, K, Forty, L, Chan, C, Knott, S, Jones, I, Craddock, N & Jones, L 2015, 'Rapid cycling as a feature of bipolar disorder and comorbid migraine', Journal of Affective Disorders, vol. 175, pp. 320-324. https://doi.org/10.1016/j.jad.2015.01.024

APA

Vancouver

Gordon-smith K, Forty L, Chan C, Knott S, Jones I, Craddock N et al. Rapid cycling as a feature of bipolar disorder and comorbid migraine. Journal of Affective Disorders. 2015 Apr 1;175:320-324. https://doi.org/10.1016/j.jad.2015.01.024

Author

Gordon-smith, K. ; Forty, L. ; Chan, C. ; Knott, S. ; Jones, I. ; Craddock, N. ; Jones, Lisa. / Rapid cycling as a feature of bipolar disorder and comorbid migraine. In: Journal of Affective Disorders. 2015 ; Vol. 175. pp. 320-324.

Bibtex

@article{21f6621d05224b678ec8549d427ae893,
title = "Rapid cycling as a feature of bipolar disorder and comorbid migraine",
abstract = "BackgroundPrevious research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample.MethodsThe lifetime clinical characteristics of 1488 individuals with BD (BPI n=1120, BPII n=368) with and without comorbid migraine were compared (n=375 vs. n=1113 respectively).ResultsIndividuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p=0.005) and have comorbid panic attacks (OR=1.842, p=0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p=0.002).LimitationsPresence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder.ConclusionsComorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.",
keywords = "Bipolar disorder, Migraine, Comorbidity, Rapid cycling",
author = "K. Gordon-smith and L. Forty and C. Chan and S. Knott and I. Jones and N. Craddock and Lisa Jones",
year = "2015",
month = apr,
day = "1",
doi = "10.1016/j.jad.2015.01.024",
language = "English",
volume = "175",
pages = "320--324",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Rapid cycling as a feature of bipolar disorder and comorbid migraine

AU - Gordon-smith, K.

AU - Forty, L.

AU - Chan, C.

AU - Knott, S.

AU - Jones, I.

AU - Craddock, N.

AU - Jones, Lisa

PY - 2015/4/1

Y1 - 2015/4/1

N2 - BackgroundPrevious research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample.MethodsThe lifetime clinical characteristics of 1488 individuals with BD (BPI n=1120, BPII n=368) with and without comorbid migraine were compared (n=375 vs. n=1113 respectively).ResultsIndividuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p=0.005) and have comorbid panic attacks (OR=1.842, p=0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p=0.002).LimitationsPresence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder.ConclusionsComorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.

AB - BackgroundPrevious research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample.MethodsThe lifetime clinical characteristics of 1488 individuals with BD (BPI n=1120, BPII n=368) with and without comorbid migraine were compared (n=375 vs. n=1113 respectively).ResultsIndividuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p=0.005) and have comorbid panic attacks (OR=1.842, p=0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p=0.002).LimitationsPresence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder.ConclusionsComorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.

KW - Bipolar disorder

KW - Migraine

KW - Comorbidity

KW - Rapid cycling

U2 - 10.1016/j.jad.2015.01.024

DO - 10.1016/j.jad.2015.01.024

M3 - Article

C2 - 25661398

VL - 175

SP - 320

EP - 324

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -