Randomised controlled trial of cognitive behavioural therapy in COPD
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- Newcastle University
- Dept of Clinical Health Psychology, Newcastle upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
- Nursing Dept, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
- Birmingham Heart England NHS Trust
- Chest Clinic, Newcastle upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
- Community Chest Team, Newcastle Upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
- Northumbria University Newcastle
Anxiety is an important comorbidity in chronic obstructive pulmonary disease (COPD). We investigated if cognitive behavioural therapy (CBT), delivered by respiratory nurses, reduced symptoms of anxiety and was cost-effective. Patients with COPD and anxiety were randomised to CBT or self-help leaflets. Anxiety, depression and quality of life were measured at baseline, 3, 6 and 12 months. A cost-effectiveness analysis was conducted from a National Health Service hospital perspective and quality-adjusted life-years estimated using the EuroQol-5D questionnaire. In total, 279 patients were recruited. Group mean change from baseline to 3 months in the Hospital Anxiety and Depression Anxiety Subscale was 3.4 (95% CI 2.62-4.17, p<0.001) for the CBT group and 1.88 (95% CI 1.19-2.55, p<0.001) in the leaflet group. The CBT group was superior to leaflets at 3 months (mean difference in the Hospital Anxiety and Depression Anxiety Subscale was 1.52, 95% CI 0.49-2.54, p=0.003). Importantly, the CBT intervention was more cost-effective than leaflets at 12 months, significantly lowering hospital admissions and attendance at emergency departments. CBT delivered by respiratory nurses is a clinically and cost-effective treatment for anxiety in patients with COPD relative to self-help leaflets.
|Number of pages||11|
|Journal||ERJ Open Research|
|Publication status||Published - 22 Nov 2018|