Randomised controlled trial of cognitive behavioural therapy in COPD

Research output: Contribution to journalArticlepeer-review

Authors

  • Karen Heslop-Marshall
  • Christine Baker
  • Julia Newton
  • Carlos Echevarria
  • Chris Stenton
  • Michelle Jambon
  • Joanne Gray
  • Kim Pearce
  • Graham Burns
  • Anthony De Soyza

Colleges, School and Institutes

External organisations

  • Newcastle University
  • Dept of Clinical Health Psychology, Newcastle upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
  • Nursing Dept, School of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Birmingham Heart England NHS Trust
  • Chest Clinic, Newcastle upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
  • Community Chest Team, Newcastle Upon Tyne Hospitals NHS Foundation Trust, RVI Hospital, Newcastle upon Tyne, UK.
  • Northumbria University Newcastle

Abstract

Anxiety is an important comorbidity in chronic obstructive pulmonary disease (COPD). We investigated if cognitive behavioural therapy (CBT), delivered by respiratory nurses, reduced symptoms of anxiety and was cost-effective. Patients with COPD and anxiety were randomised to CBT or self-help leaflets. Anxiety, depression and quality of life were measured at baseline, 3, 6 and 12 months. A cost-effectiveness analysis was conducted from a National Health Service hospital perspective and quality-adjusted life-years estimated using the EuroQol-5D questionnaire. In total, 279 patients were recruited. Group mean change from baseline to 3 months in the Hospital Anxiety and Depression Anxiety Subscale was 3.4 (95% CI 2.62-4.17, p<0.001) for the CBT group and 1.88 (95% CI 1.19-2.55, p<0.001) in the leaflet group. The CBT group was superior to leaflets at 3 months (mean difference in the Hospital Anxiety and Depression Anxiety Subscale was 1.52, 95% CI 0.49-2.54, p=0.003). Importantly, the CBT intervention was more cost-effective than leaflets at 12 months, significantly lowering hospital admissions and attendance at emergency departments. CBT delivered by respiratory nurses is a clinically and cost-effective treatment for anxiety in patients with COPD relative to self-help leaflets.

Details

Original languageEnglish
Article number00094-2018
Number of pages11
JournalERJ Open Research
Volume4
Issue number4
Publication statusPublished - 22 Nov 2018