Radiomics in paediatric neuro-oncology: A multicentre study on MRI texture analysis

Research output: Contribution to journalArticlepeer-review

Authors

  • Ahmed E Fetit
  • Daniel Rodriguez
  • Dorothee P Auer
  • Christopher A Clark
  • Richard G Grundy

External organisations

  • Research and Development, Birmingham Children's Hospital, Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham, UK.
  • Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, England.
  • University of Nottingham
  • Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • University College London
  • Institute of Digital Healthcare, WMG, University of Warwick; Coventry United Kingdom.

Abstract

Brain tumours are the most common solid cancers in children in the UK and are the most common cause of cancer deaths in this age group. Despite current advances in MRI, non-invasive diagnosis of paediatric brain tumours has yet to find its way into routine clinical practice. Radiomics, the high-throughput extraction and analysis of quantitative image features (e.g. texture), offers potential solutions for tumour characterization and decision support. In the search for diagnostic oncological markers, the primary aim of this work was to study the application of MRI texture analysis (TA) for the classification of paediatric brain tumours. A multicentre study was carried out, within a supervised classification framework, on clinical MR images, and a support vector machine (SVM) was trained with 3D textural attributes obtained from conventional MRI. To determine the cross-centre transferability of TA, an assessment of how SVM performs on unseen datasets was carried out through rigorous pairwise testing. The study also investigated the nature of features that are most likely to train classifiers that can generalize well with the data. Finally, the issue of class imbalance, which arises due to some tumour types being more common than others, was explored. For each of the tests carried out through pairwise testing, the optimal area under the receiver operating characteristic curve ranged between 76% and 86%, suggesting that the model was able to capture transferable tumour information. Feature selection results suggest that similar aspects of tumour texture are enhanced by MR images obtained at different hospitals. Our results also suggest that the availability of equally represented classes has enabled SVM to better characterize the data points. The findings of the study presented here support the use of 3D TA on conventional MR images to aid diagnostic classification of paediatric brain tumours.

Details

Original languageEnglish
Article numbere3781
JournalNMR in biomedicine
Volume31
Issue number1
Early online date26 Oct 2017
Publication statusPublished - Jan 2018

Keywords

  • Journal Article