Rac1 and Rac2 GTPases in haematopoiesis

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Rac1 and Rac2 GTPases in haematopoiesis. / Weston, Victoria; Stankovic, Tatjana.

In: BioEssays, Vol. 26, 01.01.2004, p. 221-224.

Research output: Contribution to journalReview article

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@article{9ee6183fe0ba49faa306aea35c601c22,
title = "Rac1 and Rac2 GTPases in haematopoiesis",
abstract = "The highly homologous Rac1 and Rac2 GTPases are co-expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity.",
author = "Victoria Weston and Tatjana Stankovic",
year = "2004",
month = jan,
day = "1",
doi = "10.1002/bies.20017",
language = "English",
volume = "26",
pages = "221--224",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley-VCH Verlag",

}

RIS

TY - JOUR

T1 - Rac1 and Rac2 GTPases in haematopoiesis

AU - Weston, Victoria

AU - Stankovic, Tatjana

PY - 2004/1/1

Y1 - 2004/1/1

N2 - The highly homologous Rac1 and Rac2 GTPases are co-expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity.

AB - The highly homologous Rac1 and Rac2 GTPases are co-expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity.

UR - http://www.scopus.com/inward/record.url?scp=1542344531&partnerID=8YFLogxK

U2 - 10.1002/bies.20017

DO - 10.1002/bies.20017

M3 - Review article

C2 - 14988923

VL - 26

SP - 221

EP - 224

JO - BioEssays

JF - BioEssays

SN - 0265-9247

ER -