Rac1 and Rac2 GTPases in haematopoiesis

Research output: Contribution to journalReview article

Colleges, School and Institutes


The highly homologous Rac1 and Rac2 GTPases are co-expressed in cells of haematopoietic origin and are likely to show some functional redundancy. While disruption of the Rac2 gene in mice has provided insight into some of its functions, Rac1 null mice are embryonic lethal and only recently has conditional gene disruption been possible. Consequently, two articles1,2 have recently elucidated some overlapping and unique key roles of Rac1 and Rac2 in haematopoietic processes including specialized roles in innate and humoral immunity.


Original languageEnglish
Pages (from-to)221-224
Number of pages4
Early online date1 Jan 2004
Publication statusPublished - 1 Jan 2004