Quantitative neuropathological analysis of sudden infant dealth syndrome

Research output: Contribution to journalArticle

Authors

Abstract

Detailed stereological analyses of specific regions of brains of children who had died from Sudden Infant Death Syndrome (SIDS) was undertaken to determine whether global evidence of an underlying pathology exists, contributing to an increased susceptibility to SIDS. A significant reduction in the total number of neocortical neurones and neurone volume was observed in SIDS normal birth weight (NBW) infants in comparison to controls. A significant reduction in both volume and total neurone number were also noted in the dorsal motor nucleus of the vagus in SIDS NBW group when compared with controls. Anomalies in regions of the brain involved with cardiorespiratory control (brainstem) and arousal (brainstem and neocortex) may play a crucial role in the chain of events resulting in a SIDS event.

Details

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalChild: Care, Health & Development
Volume28
Publication statusPublished - 1 Dec 2002