Quantifying effects of interactions between polyacrylic acid and chlorhexidine in dicalcium phosphate-forming cements

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Quantifying effects of interactions between polyacrylic acid and chlorhexidine in dicalcium phosphate-forming cements. / Xia, W.; Razi, M. R Mohd; Ashley, P.; Neel, E. A Abou; Hofmann, Michael; Young, A. M.

In: Journal of Materials Chemistry A, Vol. 2, No. 12, 28.03.2014, p. 1673-1680.

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Xia, W. ; Razi, M. R Mohd ; Ashley, P. ; Neel, E. A Abou ; Hofmann, Michael ; Young, A. M. / Quantifying effects of interactions between polyacrylic acid and chlorhexidine in dicalcium phosphate-forming cements. In: Journal of Materials Chemistry A. 2014 ; Vol. 2, No. 12. pp. 1673-1680.

Bibtex

@article{40c60a8d204f46de9883f64de33ccd24,
title = "Quantifying effects of interactions between polyacrylic acid and chlorhexidine in dicalcium phosphate-forming cements",
abstract = "The aim of this study was to assess how varying the ratio of aqueous 0.8 M citric acid:6 M polyacrylic acid (PAA) (3:0, 1 or 3 by weight) affected setting chemistry, mechanical properties and chlorhexidine di-acetate (CHX) release of dicalcium phosphate-forming bone cements. Cement powder included β-tricalcium phosphate (β-TCP):monocalcium phosphate monohydrate (MCPM):CHX at 1:1:(0, 0.08 or 0.16) molar ratio. Powder to liquid ratio was fixed at 3:1 by weight. Chemical setting kinetics, reactive intermediate formation and final product homogeneity were assessed by ATR FTIR and Raman mapping. Biaxial flexural strength and modulus were determined after 24 hours setting plus 24 hours in water at 37 °C and analysed using Weibull type equations. CHX release from 1 mm thick set discs was assessed over 4 weeks using UV spectroscopy. FTIR demonstrated that CHX interaction with citric acid inhibited formation of the reactive citrate/dicalcium phosphate intermediate complex that enables delay before snap set. High CHX additionally increased strength variability. Upon partial citric acid substitution with higher levels of PAA, delay before cement set was maintained. Monetite instead of brushite, however, was formed in conjuction with more stable polyacrylate complexes. These formulations had much improved strength but also greater modulus. CHX addition and interaction with PAA encouraged greater brushite instead of monetite formation. These complex interactions enabled formulations with high drug and PAA to have improved strength without increase in modulus. They also had low strength variability and better (slower) controlled release of drug. These properties are beneficial for cement use in a range of orthopaedic and dental applications.",
author = "W. Xia and Razi, {M. R Mohd} and P. Ashley and Neel, {E. A Abou} and Michael Hofmann and Young, {A. M.}",
year = "2014",
month = mar,
day = "28",
doi = "10.1039/c3tb21533d",
language = "English",
volume = "2",
pages = "1673--1680",
journal = "Journal of Materials Chemistry A",
issn = "2050-7488",
publisher = "Royal Society of Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Quantifying effects of interactions between polyacrylic acid and chlorhexidine in dicalcium phosphate-forming cements

AU - Xia, W.

AU - Razi, M. R Mohd

AU - Ashley, P.

AU - Neel, E. A Abou

AU - Hofmann, Michael

AU - Young, A. M.

PY - 2014/3/28

Y1 - 2014/3/28

N2 - The aim of this study was to assess how varying the ratio of aqueous 0.8 M citric acid:6 M polyacrylic acid (PAA) (3:0, 1 or 3 by weight) affected setting chemistry, mechanical properties and chlorhexidine di-acetate (CHX) release of dicalcium phosphate-forming bone cements. Cement powder included β-tricalcium phosphate (β-TCP):monocalcium phosphate monohydrate (MCPM):CHX at 1:1:(0, 0.08 or 0.16) molar ratio. Powder to liquid ratio was fixed at 3:1 by weight. Chemical setting kinetics, reactive intermediate formation and final product homogeneity were assessed by ATR FTIR and Raman mapping. Biaxial flexural strength and modulus were determined after 24 hours setting plus 24 hours in water at 37 °C and analysed using Weibull type equations. CHX release from 1 mm thick set discs was assessed over 4 weeks using UV spectroscopy. FTIR demonstrated that CHX interaction with citric acid inhibited formation of the reactive citrate/dicalcium phosphate intermediate complex that enables delay before snap set. High CHX additionally increased strength variability. Upon partial citric acid substitution with higher levels of PAA, delay before cement set was maintained. Monetite instead of brushite, however, was formed in conjuction with more stable polyacrylate complexes. These formulations had much improved strength but also greater modulus. CHX addition and interaction with PAA encouraged greater brushite instead of monetite formation. These complex interactions enabled formulations with high drug and PAA to have improved strength without increase in modulus. They also had low strength variability and better (slower) controlled release of drug. These properties are beneficial for cement use in a range of orthopaedic and dental applications.

AB - The aim of this study was to assess how varying the ratio of aqueous 0.8 M citric acid:6 M polyacrylic acid (PAA) (3:0, 1 or 3 by weight) affected setting chemistry, mechanical properties and chlorhexidine di-acetate (CHX) release of dicalcium phosphate-forming bone cements. Cement powder included β-tricalcium phosphate (β-TCP):monocalcium phosphate monohydrate (MCPM):CHX at 1:1:(0, 0.08 or 0.16) molar ratio. Powder to liquid ratio was fixed at 3:1 by weight. Chemical setting kinetics, reactive intermediate formation and final product homogeneity were assessed by ATR FTIR and Raman mapping. Biaxial flexural strength and modulus were determined after 24 hours setting plus 24 hours in water at 37 °C and analysed using Weibull type equations. CHX release from 1 mm thick set discs was assessed over 4 weeks using UV spectroscopy. FTIR demonstrated that CHX interaction with citric acid inhibited formation of the reactive citrate/dicalcium phosphate intermediate complex that enables delay before snap set. High CHX additionally increased strength variability. Upon partial citric acid substitution with higher levels of PAA, delay before cement set was maintained. Monetite instead of brushite, however, was formed in conjuction with more stable polyacrylate complexes. These formulations had much improved strength but also greater modulus. CHX addition and interaction with PAA encouraged greater brushite instead of monetite formation. These complex interactions enabled formulations with high drug and PAA to have improved strength without increase in modulus. They also had low strength variability and better (slower) controlled release of drug. These properties are beneficial for cement use in a range of orthopaedic and dental applications.

UR - http://www.scopus.com/inward/record.url?scp=84894688203&partnerID=8YFLogxK

U2 - 10.1039/c3tb21533d

DO - 10.1039/c3tb21533d

M3 - Article

AN - SCOPUS:84894688203

VL - 2

SP - 1673

EP - 1680

JO - Journal of Materials Chemistry A

JF - Journal of Materials Chemistry A

SN - 2050-7488

IS - 12

ER -