Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

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Colleges, School and Institutes


We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.


Original languageEnglish
Pages (from-to)1723-1726
Number of pages4
JournalBiomaterials Science
Issue number12
Early online date5 Aug 2014
Publication statusPublished - 12 Dec 2014