Quality of life outcomes following surgery for advanced ovarian cancer: a systematic review and meta-analysis

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@article{5a5b53dcb4404e968438ae752756fd83,
title = "Quality of life outcomes following surgery for advanced ovarian cancer: a systematic review and meta-analysis",
abstract = "Background: Quality of life after ovarian cancer treatment is an important goal for patients. Complex debulking surgeries and platinum based chemotherapy are often required but quality of life after surgery is rarely reported. Objectives: To describe quality of life outcomes after surgery for advanced ovarian cancer in a systematic review and meta-analysis. Search strategy: MEDLINE, EMBASE, and CENTRAL through March 2019 with no language restrictions. Selection criteria: Included studies reported quality of life in women diagnosed with primary advanced ovarian cancer, fallopian tube carcinoma or primary peritoneal cancer undergoing cytoreduction surgery. Data collection and analysis: Data on extent and timing of surgery, quality of life outcomes, and surgical complications were extracted and study quality assessed. Results: Three randomized controlled trials comparing primary surgery to neoadjuvant chemotherapy had heterogeneous quality of life outcomes with no difference between arms, although there was a clinical improvement in global quality of life scores in both arms at 6 months compared with baseline. Data from two observational studies showed no meaningful difference in quality of life scores between patients undergoing standard or extensive surgery at 6 months. Conclusions: There was no clinically important difference in the quality of life of patients undergoing either primary debulking surgery or neoadjuvant chemotherapy. There is insufficient evidence on quality of life outcomes of patients undergoing extensive or ultra-radical surgery compared with those undergoing less extensive surgery. Quality of life outcomes matter to patients, but there is little evidence to inform patient choice regarding the extent of surgery.",
keywords = "Ovarian cancer, quality of life, extensive surgery, ultra-radical surgery, debulking surgery",
author = "Satyam Kumar and Joanna Long and Sean Kehoe and Sudha Sundar and Carole Cummins",
year = "2019",
month = oct,
day = "1",
doi = "10.1136/ijgc-2018-000125",
language = "English",
volume = "29",
pages = "1285--1291",
journal = "International Journal of Gynecological Cancer",
issn = "1525-1438",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Quality of life outcomes following surgery for advanced ovarian cancer

T2 - a systematic review and meta-analysis

AU - Kumar, Satyam

AU - Long, Joanna

AU - Kehoe, Sean

AU - Sundar, Sudha

AU - Cummins, Carole

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Quality of life after ovarian cancer treatment is an important goal for patients. Complex debulking surgeries and platinum based chemotherapy are often required but quality of life after surgery is rarely reported. Objectives: To describe quality of life outcomes after surgery for advanced ovarian cancer in a systematic review and meta-analysis. Search strategy: MEDLINE, EMBASE, and CENTRAL through March 2019 with no language restrictions. Selection criteria: Included studies reported quality of life in women diagnosed with primary advanced ovarian cancer, fallopian tube carcinoma or primary peritoneal cancer undergoing cytoreduction surgery. Data collection and analysis: Data on extent and timing of surgery, quality of life outcomes, and surgical complications were extracted and study quality assessed. Results: Three randomized controlled trials comparing primary surgery to neoadjuvant chemotherapy had heterogeneous quality of life outcomes with no difference between arms, although there was a clinical improvement in global quality of life scores in both arms at 6 months compared with baseline. Data from two observational studies showed no meaningful difference in quality of life scores between patients undergoing standard or extensive surgery at 6 months. Conclusions: There was no clinically important difference in the quality of life of patients undergoing either primary debulking surgery or neoadjuvant chemotherapy. There is insufficient evidence on quality of life outcomes of patients undergoing extensive or ultra-radical surgery compared with those undergoing less extensive surgery. Quality of life outcomes matter to patients, but there is little evidence to inform patient choice regarding the extent of surgery.

AB - Background: Quality of life after ovarian cancer treatment is an important goal for patients. Complex debulking surgeries and platinum based chemotherapy are often required but quality of life after surgery is rarely reported. Objectives: To describe quality of life outcomes after surgery for advanced ovarian cancer in a systematic review and meta-analysis. Search strategy: MEDLINE, EMBASE, and CENTRAL through March 2019 with no language restrictions. Selection criteria: Included studies reported quality of life in women diagnosed with primary advanced ovarian cancer, fallopian tube carcinoma or primary peritoneal cancer undergoing cytoreduction surgery. Data collection and analysis: Data on extent and timing of surgery, quality of life outcomes, and surgical complications were extracted and study quality assessed. Results: Three randomized controlled trials comparing primary surgery to neoadjuvant chemotherapy had heterogeneous quality of life outcomes with no difference between arms, although there was a clinical improvement in global quality of life scores in both arms at 6 months compared with baseline. Data from two observational studies showed no meaningful difference in quality of life scores between patients undergoing standard or extensive surgery at 6 months. Conclusions: There was no clinically important difference in the quality of life of patients undergoing either primary debulking surgery or neoadjuvant chemotherapy. There is insufficient evidence on quality of life outcomes of patients undergoing extensive or ultra-radical surgery compared with those undergoing less extensive surgery. Quality of life outcomes matter to patients, but there is little evidence to inform patient choice regarding the extent of surgery.

KW - Ovarian cancer

KW - quality of life

KW - extensive surgery

KW - ultra-radical surgery

KW - debulking surgery

UR - http://www.scopus.com/inward/record.url?scp=85068678877&partnerID=8YFLogxK

U2 - 10.1136/ijgc-2018-000125

DO - 10.1136/ijgc-2018-000125

M3 - Article

VL - 29

SP - 1285

EP - 1291

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1525-1438

IS - 8

ER -