Pyruvate kinase, inflammation and periodontal disease

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Pyruvate kinase, inflammation and periodontal disease. / Grant, Melissa M.

In: Pathogens, Vol. 10, No. 7, 22.06.2021, p. 784.

Research output: Contribution to journalReview articlepeer-review

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@article{c7c0a1cedc1a462da626d6c00606b0c9,
title = "Pyruvate kinase, inflammation and periodontal disease",
abstract = "Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.",
keywords = "glycolysis, inflammation, pyruvate kinase, regulation",
author = "Grant, {Melissa M.}",
year = "2021",
month = jun,
day = "22",
doi = "10.3390/pathogens10070784",
language = "English",
volume = "10",
pages = "784",
journal = "Pathogens",
issn = "2076-0817",
publisher = "MDPI",
number = "7",

}

RIS

TY - JOUR

T1 - Pyruvate kinase, inflammation and periodontal disease

AU - Grant, Melissa M.

PY - 2021/6/22

Y1 - 2021/6/22

N2 - Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.

AB - Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.

KW - glycolysis

KW - inflammation

KW - pyruvate kinase

KW - regulation

U2 - 10.3390/pathogens10070784

DO - 10.3390/pathogens10070784

M3 - Review article

VL - 10

SP - 784

JO - Pathogens

JF - Pathogens

SN - 2076-0817

IS - 7

ER -