Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology

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Proton-counting radiography for proton therapy : a proof of principle using CMOS APS technology. / Poludniowski, G; Anaxagoras, T; Nieto-Camero, J; Parker, D J; Evans, P M; Parker, David; Price, Tony.

In: Physics in Medicine and Biology, Vol. 59, No. 11, 07.06.2014, p. 2569-81.

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Poludniowski, G ; Anaxagoras, T ; Nieto-Camero, J ; Parker, D J ; Evans, P M ; Parker, David ; Price, Tony. / Proton-counting radiography for proton therapy : a proof of principle using CMOS APS technology. In: Physics in Medicine and Biology. 2014 ; Vol. 59, No. 11. pp. 2569-81.

Bibtex

@article{2b63b541be724d7fa5c91d4f04c0dbe8,
title = "Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology",
abstract = "Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.",
keywords = "Cyclotrons, Metals, Oxides, Phantoms, Imaging, Proton Therapy, Scintillation Counting, Semiconductors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't",
author = "G Poludniowski and T Anaxagoras and J Nieto-Camero and Parker, {D J} and Evans, {P M} and David Parker and Tony Price",
year = "2014",
month = jun
day = "7",
doi = "10.1088/0031-9155/59/11/2569",
language = "English",
volume = "59",
pages = "2569--81",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing",
number = "11",

}

RIS

TY - JOUR

T1 - Proton-counting radiography for proton therapy

T2 - a proof of principle using CMOS APS technology

AU - Poludniowski, G

AU - Anaxagoras, T

AU - Nieto-Camero, J

AU - Parker, D J

AU - Evans, P M

AU - Parker, David

AU - Price, Tony

PY - 2014/6/7

Y1 - 2014/6/7

N2 - Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.

AB - Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.

KW - Cyclotrons

KW - Metals

KW - Oxides

KW - Phantoms, Imaging

KW - Proton Therapy

KW - Scintillation Counting

KW - Semiconductors

KW - Tomography, X-Ray Computed

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1088/0031-9155/59/11/2569

DO - 10.1088/0031-9155/59/11/2569

M3 - Article

C2 - 24785680

VL - 59

SP - 2569

EP - 2581

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 11

ER -