TY - JOUR
T1 - Protocol for Past BP: a randomised controlled trial of different blood pressure targets for people with a history of stroke of transient ischaemic attack (TIA) in primary care
AU - Fletcher, Kate
AU - Mant, J
AU - McManus, Richard
AU - Campbell, Sarah
AU - Betts, J
AU - Taylor, Clare
AU - Virdee, Satnam
AU - Martin, Una
AU - Greenfield, Sheila
AU - Ford, G
AU - Freemantle, Nick
AU - Hobbs, Frederick
PY - 2010/8/9
Y1 - 2010/8/9
N2 - Background
Blood pressure (BP) lowering in people who have had a stroke or transient ischaemic attack (TIA) leads to reduced risk of further stroke. However, it is not clear what the target BP should be, since intensification of therapy may lead to additional adverse effects. PAST BP will determine whether more intensive BP targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life.
Methods/Design
This is a randomised controlled trial (RCT) in patients with a past history of stroke or TIA. Patients will be randomised to two groups and will either have their blood pressure (BP) lowered intensively to a target of 130 mmHg systolic, (or by 10 mmHg if the baseline systolic pressure is between 125 and 140 mmHg) compared to a standard group where the BP will be reduced to a target of 140 mmHg systolic. Patients will be managed by their practice at 1-3 month intervals depending on level of BP and followed-up by the research team at six monthly intervals for 12 months.
610 patients will be recruited from approximately 50 general practices. The following exclusion criteria will be applied: systolic BP
AB - Background
Blood pressure (BP) lowering in people who have had a stroke or transient ischaemic attack (TIA) leads to reduced risk of further stroke. However, it is not clear what the target BP should be, since intensification of therapy may lead to additional adverse effects. PAST BP will determine whether more intensive BP targets can be achieved in a primary care setting, and whether more intensive therapy is associated with adverse effects on quality of life.
Methods/Design
This is a randomised controlled trial (RCT) in patients with a past history of stroke or TIA. Patients will be randomised to two groups and will either have their blood pressure (BP) lowered intensively to a target of 130 mmHg systolic, (or by 10 mmHg if the baseline systolic pressure is between 125 and 140 mmHg) compared to a standard group where the BP will be reduced to a target of 140 mmHg systolic. Patients will be managed by their practice at 1-3 month intervals depending on level of BP and followed-up by the research team at six monthly intervals for 12 months.
610 patients will be recruited from approximately 50 general practices. The following exclusion criteria will be applied: systolic BP
U2 - 10.1186/1471-2261-10-37
DO - 10.1186/1471-2261-10-37
M3 - Article
C2 - 20696047
VL - 10
JO - BMC Cardiovascular Disorders
JF - BMC Cardiovascular Disorders
M1 - 37
ER -