Protocol for a feasibility study of smoking cessation in the surgical pathway before major lung surgery: Project MURRAY

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Protocol for a feasibility study of smoking cessation in the surgical pathway before major lung surgery: Project MURRAY. / Lugg, Sebastian T; Kerr, Amy; Kadiri, Salma; Budacan, Alina-Maria; Farley, Amanda; Perski, Olga; West, Robert; Brown, Jamie ; Thickett, David R; Naidu, Babu.

In: BMJ open, 06.11.2020.

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@article{ee630e7e18b04712a4f2ffc6517791cc,
title = "Protocol for a feasibility study of smoking cessation in the surgical pathway before major lung surgery: Project MURRAY",
abstract = "Introduction: Smoking prior to major thoracic surgery is the biggest risk factor for development of postoperative pulmonary complications, with 1 in 5 patients continuing to smoke before surgery. Current guidance is that all patients should stop smoking before elective surgery yet very few are offered specialist smoking cessation support. Patients would prefer support within the thoracic surgical pathway. No study has addressed the effectiveness of such an intervention in this setting on cessation. The overall aim is to determine in patients who undergo major elective thoracic surgery whether an intervention integrated (INT) into the surgical pathway improves smoking cessation rates compared with usual care (UC) of standard community/hospital based NHS smoking support. This pilot study will evaluate feasibility of a substantive trial.Methods and analysis: Project MURRAY is a trial comparing the effectiveness of INT and UC on smoking cessation. INT is pharmacotherapy and a hybrid of behavioural support delivered by the trained healthcare practitioners (HCPs) in the thoracic surgical pathway and a complimentary web-based application. This pilot study will evaluate the feasibility of a substantive trial and study processes in 5 adult thoracic centres including the University Hospitals Birmingham NHS Foundation Trust. The primary objective is to establish the proportion of those eligible who agree to participate. Secondary objectives include evaluation of study processes. Analyses of feasibility and patient-reported outcomes will take the form of simple descriptive statistics and where appropriate, point estimates of effects sizes and associated 95% CIs. Ethics and dissemination: The study has obtained ethical approval from NHS Research Ethics Committee (REC number 19/WM/0097). Dissemination plan includes: informing patients and HCPs; engaging multidisciplinary professionals to support a proposal of a definitive trial and submission for a full application dependent on the success of the study.Trial Registration Number: NCT04190966; Pre-results",
keywords = "adult anaesthesia, adult thoracic medicine, cardiothoracic surgery",
author = "Lugg, {Sebastian T} and Amy Kerr and Salma Kadiri and Alina-Maria Budacan and Amanda Farley and Olga Perski and Robert West and Jamie Brown and Thickett, {David R} and Babu Naidu",
year = "2020",
month = nov,
day = "6",
doi = "10.1136/bmjopen-2019-036568",
language = "English",
journal = "BMJ open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - Protocol for a feasibility study of smoking cessation in the surgical pathway before major lung surgery: Project MURRAY

AU - Lugg, Sebastian T

AU - Kerr, Amy

AU - Kadiri, Salma

AU - Budacan, Alina-Maria

AU - Farley, Amanda

AU - Perski, Olga

AU - West, Robert

AU - Brown, Jamie

AU - Thickett, David R

AU - Naidu, Babu

PY - 2020/11/6

Y1 - 2020/11/6

N2 - Introduction: Smoking prior to major thoracic surgery is the biggest risk factor for development of postoperative pulmonary complications, with 1 in 5 patients continuing to smoke before surgery. Current guidance is that all patients should stop smoking before elective surgery yet very few are offered specialist smoking cessation support. Patients would prefer support within the thoracic surgical pathway. No study has addressed the effectiveness of such an intervention in this setting on cessation. The overall aim is to determine in patients who undergo major elective thoracic surgery whether an intervention integrated (INT) into the surgical pathway improves smoking cessation rates compared with usual care (UC) of standard community/hospital based NHS smoking support. This pilot study will evaluate feasibility of a substantive trial.Methods and analysis: Project MURRAY is a trial comparing the effectiveness of INT and UC on smoking cessation. INT is pharmacotherapy and a hybrid of behavioural support delivered by the trained healthcare practitioners (HCPs) in the thoracic surgical pathway and a complimentary web-based application. This pilot study will evaluate the feasibility of a substantive trial and study processes in 5 adult thoracic centres including the University Hospitals Birmingham NHS Foundation Trust. The primary objective is to establish the proportion of those eligible who agree to participate. Secondary objectives include evaluation of study processes. Analyses of feasibility and patient-reported outcomes will take the form of simple descriptive statistics and where appropriate, point estimates of effects sizes and associated 95% CIs. Ethics and dissemination: The study has obtained ethical approval from NHS Research Ethics Committee (REC number 19/WM/0097). Dissemination plan includes: informing patients and HCPs; engaging multidisciplinary professionals to support a proposal of a definitive trial and submission for a full application dependent on the success of the study.Trial Registration Number: NCT04190966; Pre-results

AB - Introduction: Smoking prior to major thoracic surgery is the biggest risk factor for development of postoperative pulmonary complications, with 1 in 5 patients continuing to smoke before surgery. Current guidance is that all patients should stop smoking before elective surgery yet very few are offered specialist smoking cessation support. Patients would prefer support within the thoracic surgical pathway. No study has addressed the effectiveness of such an intervention in this setting on cessation. The overall aim is to determine in patients who undergo major elective thoracic surgery whether an intervention integrated (INT) into the surgical pathway improves smoking cessation rates compared with usual care (UC) of standard community/hospital based NHS smoking support. This pilot study will evaluate feasibility of a substantive trial.Methods and analysis: Project MURRAY is a trial comparing the effectiveness of INT and UC on smoking cessation. INT is pharmacotherapy and a hybrid of behavioural support delivered by the trained healthcare practitioners (HCPs) in the thoracic surgical pathway and a complimentary web-based application. This pilot study will evaluate the feasibility of a substantive trial and study processes in 5 adult thoracic centres including the University Hospitals Birmingham NHS Foundation Trust. The primary objective is to establish the proportion of those eligible who agree to participate. Secondary objectives include evaluation of study processes. Analyses of feasibility and patient-reported outcomes will take the form of simple descriptive statistics and where appropriate, point estimates of effects sizes and associated 95% CIs. Ethics and dissemination: The study has obtained ethical approval from NHS Research Ethics Committee (REC number 19/WM/0097). Dissemination plan includes: informing patients and HCPs; engaging multidisciplinary professionals to support a proposal of a definitive trial and submission for a full application dependent on the success of the study.Trial Registration Number: NCT04190966; Pre-results

KW - adult anaesthesia

KW - adult thoracic medicine

KW - cardiothoracic surgery

U2 - 10.1136/bmjopen-2019-036568

DO - 10.1136/bmjopen-2019-036568

M3 - Article

C2 - 33158819

JO - BMJ open

JF - BMJ open

SN - 2044-6055

ER -