Protein-nanoparticle interactions

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • UNIVERSITY COLLEGE DUBLIN

Abstract

The key role of protein-nanoparticle interactions in nanomedicine and nanotoxicity has begun to emerge recently with the development of the idea of the nanoparticle-protein 'corona'. This dynamic layer of proteins (and other biomolecules) adsorbs to nanoparticle surfaces immediately upon contact with living systems. While within the biomaterials field the role of adsorbed molecules in cellular responses is acknowledged, there are several new issues at stake where nanoparticles are concerned. We show here that highly selective protein adsorption, added to the fact that particles can reach subcellular locations, results in significant new potential impacts for nanoparticles on protein interactions and cellular behavior.

Bibliographic note

Copyright 2008 Elsevier B.V., All rights reserved.

Details

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalNano Today: an international rapid reviews journal
Volume3
Issue number1-2
Publication statusPublished - 1 Feb 2008