Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate

Research output: Contribution to journalArticle

Standard

Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate. / Lee, C J; Lock, R A; Andrew, P W; Mitchell, T J; Hansman, D; Paton, J C.

In: Vaccine, Vol. 12, No. 10, 08.1994, p. 875-8.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{2b93c6763cfa42e5a711e8a72d20f7e5,
title = "Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate",
abstract = "The immunogenicity and protective efficacy of a conjugate of Streptococcus pneumoniae type 19F polysaccharide and a genetically toxoided derivative of the pneumococcal toxin pneumolysin was investigated in an infant mouse model. The conjugate was administered to Balb/c mice during pregnancy and/or lactation, and to their offspring during early infancy. The anti-polysaccharide and anti-pneumolysin titres of the immunized infant mice were significantly higher than those of non-immunized controls. When the infant mice were challenged with type 19F pneumococci, the bacteria were cleared more effectively from the blood of immunized mice than from that of control mice. The survival rate for the immunized mice was also significantly higher than that for the control group. These results indicate that highly protective anti-pneumococcal responses can be induced in infant mice by immunization with the conjugate during gestation or early infancy, and suggest a possible role for pneumolysoid-polysaccharide conjugates as human vaccine components.",
keywords = "Animals, Animals, Newborn, Antibodies, Bacterial, Bacterial Proteins, Bacterial Vaccines, Female, Immunization, Mice, Mice, Inbred BALB C, Polysaccharides, Bacterial, Pregnancy, Streptococcus pneumoniae, Streptolysins, Vaccines, Conjugate",
author = "Lee, {C J} and Lock, {R A} and Andrew, {P W} and Mitchell, {T J} and D Hansman and Paton, {J C}",
year = "1994",
month = aug,
language = "English",
volume = "12",
pages = "875--8",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - Protection of infant mice from challenge with Streptococcus pneumoniae type 19F by immunization with a type 19F polysaccharide--pneumolysoid conjugate

AU - Lee, C J

AU - Lock, R A

AU - Andrew, P W

AU - Mitchell, T J

AU - Hansman, D

AU - Paton, J C

PY - 1994/8

Y1 - 1994/8

N2 - The immunogenicity and protective efficacy of a conjugate of Streptococcus pneumoniae type 19F polysaccharide and a genetically toxoided derivative of the pneumococcal toxin pneumolysin was investigated in an infant mouse model. The conjugate was administered to Balb/c mice during pregnancy and/or lactation, and to their offspring during early infancy. The anti-polysaccharide and anti-pneumolysin titres of the immunized infant mice were significantly higher than those of non-immunized controls. When the infant mice were challenged with type 19F pneumococci, the bacteria were cleared more effectively from the blood of immunized mice than from that of control mice. The survival rate for the immunized mice was also significantly higher than that for the control group. These results indicate that highly protective anti-pneumococcal responses can be induced in infant mice by immunization with the conjugate during gestation or early infancy, and suggest a possible role for pneumolysoid-polysaccharide conjugates as human vaccine components.

AB - The immunogenicity and protective efficacy of a conjugate of Streptococcus pneumoniae type 19F polysaccharide and a genetically toxoided derivative of the pneumococcal toxin pneumolysin was investigated in an infant mouse model. The conjugate was administered to Balb/c mice during pregnancy and/or lactation, and to their offspring during early infancy. The anti-polysaccharide and anti-pneumolysin titres of the immunized infant mice were significantly higher than those of non-immunized controls. When the infant mice were challenged with type 19F pneumococci, the bacteria were cleared more effectively from the blood of immunized mice than from that of control mice. The survival rate for the immunized mice was also significantly higher than that for the control group. These results indicate that highly protective anti-pneumococcal responses can be induced in infant mice by immunization with the conjugate during gestation or early infancy, and suggest a possible role for pneumolysoid-polysaccharide conjugates as human vaccine components.

KW - Animals

KW - Animals, Newborn

KW - Antibodies, Bacterial

KW - Bacterial Proteins

KW - Bacterial Vaccines

KW - Female

KW - Immunization

KW - Mice

KW - Mice, Inbred BALB C

KW - Polysaccharides, Bacterial

KW - Pregnancy

KW - Streptococcus pneumoniae

KW - Streptolysins

KW - Vaccines, Conjugate

M3 - Article

C2 - 7975828

VL - 12

SP - 875

EP - 878

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 10

ER -