Proportion of Pelvic Inflammatory Disease caused by Chlamydia trachomatis: consistent picture from different methods

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Proportion of Pelvic Inflammatory Disease caused by Chlamydia trachomatis: consistent picture from different methods. / Price, Malcolm; Ades, A.E; Welton, Nicky J; Simms, Ian; Macleod, John; Horner, Paddy J.

In: The Journal of Infectious Diseases, Vol. 214, No. 4, 15.08.2016, p. 617-624.

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Price, Malcolm ; Ades, A.E ; Welton, Nicky J ; Simms, Ian ; Macleod, John ; Horner, Paddy J. / Proportion of Pelvic Inflammatory Disease caused by Chlamydia trachomatis: consistent picture from different methods. In: The Journal of Infectious Diseases. 2016 ; Vol. 214, No. 4. pp. 617-624.

Bibtex

@article{787e4cfc79264aeaaf86d5178db9cd36,
title = "Proportion of Pelvic Inflammatory Disease caused by Chlamydia trachomatis: consistent picture from different methods",
abstract = "Background. Pelvic inflammatory disease (PID) is a leading cause of both tubal factor infertility and ectopic pregnancy. Chlamydia trachomatis is an important risk factor for PID, but the proportion of PID cases caused by C. trachomatis is unclear. Estimates of this are required to evaluate control measures.Methods. We consider 5 separate methods of estimating age-group-specific population excess fractions (PEFs) of PID due to C. trachomatis, using routine data, surveys, case-control studies, and randomized controlled trials, and apply these to data from the United Kingdom before introduction of the National Chlamydia Screening Programme.Results. As they are informed by randomized comparisons and national exposure and outcome estimates, our preferred estimates of the proportion of PID cases caused by C. trachomatis are 35% (95% credible interval [CrI], 11%–69%) in women aged 16–24 years and 20% (95% CrI, 6%–38%) in women aged 16–44 years in the United Kingdom. There is a fair degree of consistency between adjusted estimates of PEF, but all have wide 95% CrIs. The PEF decreases from 53.5% (95% CrI, 15.6%–100%) in women aged 16–19 years to 11.5% (95% CrI, 3.0%–25.7%) in women aged 35–44 years.Conclusions. The PEFs of PID due to C. trachomatis decline steeply with age by a factor of around 5-fold between younger and older women. Further studies of the etiology of PID in different age groups are required.",
keywords = "Chlamydia trachomatis, pelvic inflammatory disease, population attributable fraction, population excess fraction, meta-analysis, Bayesian, evidence synthesis",
author = "Malcolm Price and A.E Ades and Welton, {Nicky J} and Ian Simms and John Macleod and Horner, {Paddy J}",
year = "2016",
month = aug,
day = "15",
doi = "10.1093/infdis/jiw178",
language = "English",
volume = "214",
pages = "617--624",
journal = "The Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Proportion of Pelvic Inflammatory Disease caused by Chlamydia trachomatis: consistent picture from different methods

AU - Price, Malcolm

AU - Ades, A.E

AU - Welton, Nicky J

AU - Simms, Ian

AU - Macleod, John

AU - Horner, Paddy J

PY - 2016/8/15

Y1 - 2016/8/15

N2 - Background. Pelvic inflammatory disease (PID) is a leading cause of both tubal factor infertility and ectopic pregnancy. Chlamydia trachomatis is an important risk factor for PID, but the proportion of PID cases caused by C. trachomatis is unclear. Estimates of this are required to evaluate control measures.Methods. We consider 5 separate methods of estimating age-group-specific population excess fractions (PEFs) of PID due to C. trachomatis, using routine data, surveys, case-control studies, and randomized controlled trials, and apply these to data from the United Kingdom before introduction of the National Chlamydia Screening Programme.Results. As they are informed by randomized comparisons and national exposure and outcome estimates, our preferred estimates of the proportion of PID cases caused by C. trachomatis are 35% (95% credible interval [CrI], 11%–69%) in women aged 16–24 years and 20% (95% CrI, 6%–38%) in women aged 16–44 years in the United Kingdom. There is a fair degree of consistency between adjusted estimates of PEF, but all have wide 95% CrIs. The PEF decreases from 53.5% (95% CrI, 15.6%–100%) in women aged 16–19 years to 11.5% (95% CrI, 3.0%–25.7%) in women aged 35–44 years.Conclusions. The PEFs of PID due to C. trachomatis decline steeply with age by a factor of around 5-fold between younger and older women. Further studies of the etiology of PID in different age groups are required.

AB - Background. Pelvic inflammatory disease (PID) is a leading cause of both tubal factor infertility and ectopic pregnancy. Chlamydia trachomatis is an important risk factor for PID, but the proportion of PID cases caused by C. trachomatis is unclear. Estimates of this are required to evaluate control measures.Methods. We consider 5 separate methods of estimating age-group-specific population excess fractions (PEFs) of PID due to C. trachomatis, using routine data, surveys, case-control studies, and randomized controlled trials, and apply these to data from the United Kingdom before introduction of the National Chlamydia Screening Programme.Results. As they are informed by randomized comparisons and national exposure and outcome estimates, our preferred estimates of the proportion of PID cases caused by C. trachomatis are 35% (95% credible interval [CrI], 11%–69%) in women aged 16–24 years and 20% (95% CrI, 6%–38%) in women aged 16–44 years in the United Kingdom. There is a fair degree of consistency between adjusted estimates of PEF, but all have wide 95% CrIs. The PEF decreases from 53.5% (95% CrI, 15.6%–100%) in women aged 16–19 years to 11.5% (95% CrI, 3.0%–25.7%) in women aged 35–44 years.Conclusions. The PEFs of PID due to C. trachomatis decline steeply with age by a factor of around 5-fold between younger and older women. Further studies of the etiology of PID in different age groups are required.

KW - Chlamydia trachomatis

KW - pelvic inflammatory disease

KW - population attributable fraction

KW - population excess fraction

KW - meta-analysis

KW - Bayesian

KW - evidence synthesis

U2 - 10.1093/infdis/jiw178

DO - 10.1093/infdis/jiw178

M3 - Article

VL - 214

SP - 617

EP - 624

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -