Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia

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Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia. / Ponce-Alonso, Manuel ; Fernandez-Felix, Borja M. ; Halperin, Ana ; Rodıguez-Domınguez, Mario ; Sanchez-Dıaz, Ana M ; Canton, Rafael ; Muriel, Alfonso; Zamora, Javier; del Campo, Rosa .

In: International Journal of Infectious Diseases, Vol. 110, 09.2021, p. 36-44.

Research output: Contribution to journalArticlepeer-review

Harvard

Ponce-Alonso, M, Fernandez-Felix, BM, Halperin, A, Rodıguez-Domınguez, M, Sanchez-Dıaz, AM, Canton, R, Muriel, A, Zamora, J & del Campo, R 2021, 'Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia', International Journal of Infectious Diseases, vol. 110, pp. 36-44. https://doi.org/10.1016/j.ijid.2021.07.034

APA

Ponce-Alonso, M., Fernandez-Felix, B. M., Halperin, A., Rodıguez-Domınguez, M., Sanchez-Dıaz, A. M., Canton, R., Muriel, A., Zamora, J., & del Campo, R. (2021). Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia. International Journal of Infectious Diseases, 110, 36-44. https://doi.org/10.1016/j.ijid.2021.07.034

Vancouver

Author

Ponce-Alonso, Manuel ; Fernandez-Felix, Borja M. ; Halperin, Ana ; Rodıguez-Domınguez, Mario ; Sanchez-Dıaz, Ana M ; Canton, Rafael ; Muriel, Alfonso ; Zamora, Javier ; del Campo, Rosa . / Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia. In: International Journal of Infectious Diseases. 2021 ; Vol. 110. pp. 36-44.

Bibtex

@article{663aedae41f8445f81249b7f0ad434a4,
title = "Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia",
abstract = "Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence on the prognosis of the infection. The aim of the present work was to explore this assumption in patients admitted to the ICU with septic bacteremia.Methods: Retrospective analysis (2006-2017) in septic patients with microbiologically confirmed bacteremia (n=440). Risk of ICU and in-hospital mortality in males respect to females was compared by a univariate analysis and a propensity score analysis integrating their clinical characteristics.Results: Sepsis occurred more frequently in males (80.2% vs 76.1%) as well as inhospital (48.0% vs 41.3%) and ICU (39.9% vs 36.5%) mortality. Univariate analyses showed that males had a higher Charlson comorbidity index and a poorer McCabe prognostic score. However, the propensity score in 296 matched patients demonstrated that females had higher risk of both ICU (OR 1.39; 95% CI 0.89 to 2.19) and in-hospital mortality (OR 1.18; 95% CI 0.77 to 1.83), but without statistical significance.Conclusion: Men with sepsis have worse clinical characteristics when admitted to the ICU, but sex has no influence on mortality. Our data contributes to help reduce the sexdependent gap present in health care provision.",
keywords = "Sex, ICU, sepsis, mortality, propensity-score",
author = "Manuel Ponce-Alonso and Fernandez-Felix, {Borja M.} and Ana Halperin and Mario Rodıguez-Domınguez and Sanchez-Dıaz, {Ana M} and Rafael Canton and Alfonso Muriel and Javier Zamora and {del Campo}, Rosa",
year = "2021",
month = sep,
doi = "10.1016/j.ijid.2021.07.034",
language = "English",
volume = "110",
pages = "36--44",
journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Propensity-score analysis reveals that sex is not a prognosis factor for mortality in intensive care unit-admitted patients with septic bacteremia

AU - Ponce-Alonso, Manuel

AU - Fernandez-Felix, Borja M.

AU - Halperin, Ana

AU - Rodıguez-Domınguez, Mario

AU - Sanchez-Dıaz, Ana M

AU - Canton, Rafael

AU - Muriel, Alfonso

AU - Zamora, Javier

AU - del Campo, Rosa

PY - 2021/9

Y1 - 2021/9

N2 - Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence on the prognosis of the infection. The aim of the present work was to explore this assumption in patients admitted to the ICU with septic bacteremia.Methods: Retrospective analysis (2006-2017) in septic patients with microbiologically confirmed bacteremia (n=440). Risk of ICU and in-hospital mortality in males respect to females was compared by a univariate analysis and a propensity score analysis integrating their clinical characteristics.Results: Sepsis occurred more frequently in males (80.2% vs 76.1%) as well as inhospital (48.0% vs 41.3%) and ICU (39.9% vs 36.5%) mortality. Univariate analyses showed that males had a higher Charlson comorbidity index and a poorer McCabe prognostic score. However, the propensity score in 296 matched patients demonstrated that females had higher risk of both ICU (OR 1.39; 95% CI 0.89 to 2.19) and in-hospital mortality (OR 1.18; 95% CI 0.77 to 1.83), but without statistical significance.Conclusion: Men with sepsis have worse clinical characteristics when admitted to the ICU, but sex has no influence on mortality. Our data contributes to help reduce the sexdependent gap present in health care provision.

AB - Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence on the prognosis of the infection. The aim of the present work was to explore this assumption in patients admitted to the ICU with septic bacteremia.Methods: Retrospective analysis (2006-2017) in septic patients with microbiologically confirmed bacteremia (n=440). Risk of ICU and in-hospital mortality in males respect to females was compared by a univariate analysis and a propensity score analysis integrating their clinical characteristics.Results: Sepsis occurred more frequently in males (80.2% vs 76.1%) as well as inhospital (48.0% vs 41.3%) and ICU (39.9% vs 36.5%) mortality. Univariate analyses showed that males had a higher Charlson comorbidity index and a poorer McCabe prognostic score. However, the propensity score in 296 matched patients demonstrated that females had higher risk of both ICU (OR 1.39; 95% CI 0.89 to 2.19) and in-hospital mortality (OR 1.18; 95% CI 0.77 to 1.83), but without statistical significance.Conclusion: Men with sepsis have worse clinical characteristics when admitted to the ICU, but sex has no influence on mortality. Our data contributes to help reduce the sexdependent gap present in health care provision.

KW - Sex

KW - ICU

KW - sepsis

KW - mortality

KW - propensity-score

U2 - 10.1016/j.ijid.2021.07.034

DO - 10.1016/j.ijid.2021.07.034

M3 - Article

VL - 110

SP - 36

EP - 44

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -