Promoting both quantity and quality of life, Part 2. Methodological Considerations for the Assessment of Health-Related Quality of Life (HRQoL) in Clinical Trials

Research output: Contribution to journalArticle


This article aims to address key methodological issues that should be considered when assessing health-related quality of life (HRQoL) in a clinical trial. These include justification for the selection of HRQoL as a primary or secondary outcome and choice of an appropriate instrument to assess HRQoL, which meets basic psychometric properties. In addition we consider ways to minimize bias within the trial through optimization of compliance and timing of assessments.


Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalJournal of Clinical Pharmacy and Therapeutics
Issue number1
Publication statusPublished - 1 Jan 2004