TY - JOUR
T1 - Pro-inflammatory cytokines IL6, TNF-alpha, IL1beta, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis.
AU - Watkin, Richard
AU - Harper, LV
AU - Vernallis, AB
AU - Lang, S
AU - Lambert, PA
AU - Ranasinghe, Aaron
AU - Elliott, Thomas
PY - 2007/9/1
Y1 - 2007/9/1
N2 - OBJECTIVE: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). PATIENTS AND METHODS: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL1beta), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). RESULTS: Serum levels of IL6, IL1beta and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-alpha and LBP were not elevated. CONCLUSION: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
AB - OBJECTIVE: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). PATIENTS AND METHODS: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL1beta), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). RESULTS: Serum levels of IL6, IL1beta and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-alpha and LBP were not elevated. CONCLUSION: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
U2 - 10.1016/j.jinf.2007.05.174
DO - 10.1016/j.jinf.2007.05.174
M3 - Article
C2 - 17586049
SN - 1532-2742
VL - 55
SP - 220
EP - 225
JO - Journal of Infection
JF - Journal of Infection
IS - 3
ER -