Programmable polymer-DNA hydrogels with dual input and multiscale responses

Research output: Contribution to journalArticlepeer-review


  • G. Sicilia
  • C. Grainger-Boultby
  • N. Francini
  • J.P. Magnusson
  • A.O. Saeed
  • S.G. Spain
  • C. Alexander

Colleges, School and Institutes


Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano- to micro-scale.


Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalBiomaterials Science
Issue number2
Publication statusPublished - 1 Feb 2014