Progesterone for the Prevention of Preterm Birth: A Critical Evaluation of Evidence

Arri Coomarasamy, Shakila Thangaratinam, Harold Gee, Khalid Khan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A systematic review of the literature identified nine randomised trials that evaluated the effects of progestational agents in the prevention of preterm delivery. These studies were of variable quality. Meta-analyses showed reductions in delivery rates before 37 weeks (OR 0.42, 95% Cl 0.31-0.57) and 34 weeks (OR 0.51, 95% CI 0.34-0.77) as well as in respiratory distress syndrome (OR 0.55, 95% Cl 0.31-0.96) with progestational agents. A cumulative meta-analysis showed that the treatment benefit for the outcome of delivery before 37 weeks exceeded the conventional level of statistical significance in 1975 (p <0.01); by 1985, the p-value was
Original languageEnglish
Pages (from-to)111-8
Number of pages8
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Volume129(2)
Publication statusPublished - 1 Dec 2006

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