Progenitor cells of the biliary lineage

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Progenitor cells of the biliary lineage. / Crosby, Heather; Nijjar, Sarbjit; de Ville de Goyet, Jean; Kelly, Deirdre; Strain, Alastair.

In: Seminars in Cell and Developmental Biology, Vol. 13, No. 6, 01.12.2002, p. 397-403.

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Crosby, Heather ; Nijjar, Sarbjit ; de Ville de Goyet, Jean ; Kelly, Deirdre ; Strain, Alastair. / Progenitor cells of the biliary lineage. In: Seminars in Cell and Developmental Biology. 2002 ; Vol. 13, No. 6. pp. 397-403.

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@article{57add3b914a343b8b6f6ef736c0ddb91,
title = "Progenitor cells of the biliary lineage",
abstract = "Stem-like cells have been identified in liver that are able to differentiate in vivo and in culture to biliary epithelial cells (BEC), hepatocytes and oval cells. The growth factors/cytokines and signal pathways required for the differentiation processes are beginning to be evaluated. There is increasing evidence to suggest that these stem-like cells may originate from both the bone marrow population or from a precursor remnant from liver embryogenesis, as they share many of the same markers (CD34, c-kit, CD45). Most recently, it has been shown that a population of progenitor cells can copurify with mesenchymal bone marrow cells and differentiate under specific culture conditions to form both hepatic epithelial and also endothelial cells. The interaction of haemopoietic and mesenchymal stem cells needs further evaluation. The close association of ductular reactive cells and neovessels in end-stage cholestatic liver diseases and the relation to Jagged/Notch signalling pathway may be important in the regulation of stem cells to form both biliary epithelial and endothelial cells.",
author = "Heather Crosby and Sarbjit Nijjar and {de Ville de Goyet}, Jean and Deirdre Kelly and Alastair Strain",
year = "2002",
month = dec,
day = "1",
doi = "10.1016/S108495210200126X",
language = "English",
volume = "13",
pages = "397--403",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Progenitor cells of the biliary lineage

AU - Crosby, Heather

AU - Nijjar, Sarbjit

AU - de Ville de Goyet, Jean

AU - Kelly, Deirdre

AU - Strain, Alastair

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Stem-like cells have been identified in liver that are able to differentiate in vivo and in culture to biliary epithelial cells (BEC), hepatocytes and oval cells. The growth factors/cytokines and signal pathways required for the differentiation processes are beginning to be evaluated. There is increasing evidence to suggest that these stem-like cells may originate from both the bone marrow population or from a precursor remnant from liver embryogenesis, as they share many of the same markers (CD34, c-kit, CD45). Most recently, it has been shown that a population of progenitor cells can copurify with mesenchymal bone marrow cells and differentiate under specific culture conditions to form both hepatic epithelial and also endothelial cells. The interaction of haemopoietic and mesenchymal stem cells needs further evaluation. The close association of ductular reactive cells and neovessels in end-stage cholestatic liver diseases and the relation to Jagged/Notch signalling pathway may be important in the regulation of stem cells to form both biliary epithelial and endothelial cells.

AB - Stem-like cells have been identified in liver that are able to differentiate in vivo and in culture to biliary epithelial cells (BEC), hepatocytes and oval cells. The growth factors/cytokines and signal pathways required for the differentiation processes are beginning to be evaluated. There is increasing evidence to suggest that these stem-like cells may originate from both the bone marrow population or from a precursor remnant from liver embryogenesis, as they share many of the same markers (CD34, c-kit, CD45). Most recently, it has been shown that a population of progenitor cells can copurify with mesenchymal bone marrow cells and differentiate under specific culture conditions to form both hepatic epithelial and also endothelial cells. The interaction of haemopoietic and mesenchymal stem cells needs further evaluation. The close association of ductular reactive cells and neovessels in end-stage cholestatic liver diseases and the relation to Jagged/Notch signalling pathway may be important in the regulation of stem cells to form both biliary epithelial and endothelial cells.

UR - http://www.scopus.com/inward/record.url?scp=0036920045&partnerID=8YFLogxK

U2 - 10.1016/S108495210200126X

DO - 10.1016/S108495210200126X

M3 - Article

C2 - 12468239

VL - 13

SP - 397

EP - 403

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 6

ER -