Progenitor cells are mobilized by acute physiological stress but not beta-adrenergic receptor agonist infusion

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Progenitor cells are mobilized by acute physiological stress but not beta-adrenergic receptor agonist infusion. / Riddell, Natalie; Burns, Victoria; Wallace, Graham; Edwards, Kate M; Drayson, Mark; Redwine, Laura S; Hong, Suzi; Bui, Jack C; Fischer, Johannes C; Mills, Paul J; Bosch, Jos.

In: Brain, Behaviour, and Immunity, Vol. 49, 10.2015, p. 49-53.

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Riddell, Natalie ; Burns, Victoria ; Wallace, Graham ; Edwards, Kate M ; Drayson, Mark ; Redwine, Laura S ; Hong, Suzi ; Bui, Jack C ; Fischer, Johannes C ; Mills, Paul J ; Bosch, Jos. / Progenitor cells are mobilized by acute physiological stress but not beta-adrenergic receptor agonist infusion. In: Brain, Behaviour, and Immunity. 2015 ; Vol. 49. pp. 49-53.

Bibtex

@article{114091a526ee441d9c2231e4689e6572,
title = "Progenitor cells are mobilized by acute physiological stress but not beta-adrenergic receptor agonist infusion",
abstract = "ObjectivesStimuli that activate the sympathetic nervous system, such as acute psychological stress, rapidly invoke a robust mobilization of lymphocytes into the circulation. Experimental animal studies suggest that bone marrow-derived progenitor cells (PCs) also mobilize in response to sympathetic stimulation. Here we tested the effects of acute psychological stress and brief pharmacological β-adrenergic (βAR) stimulation on peripheral PC numbers in humans.MethodsIn two studies, we investigated PC mobilization in response to an acute speech task (n = 26) and βAR-agonist (isoproterenol) infusion (n = 20). A subset of 8 participants also underwent the infusion protocol with concomitant administration of the βAR-antagonist propranolol. Flow cytometry was used to enumerate lymphocyte subsets, total progenitor cells, total haematopoietic stem cells (HSC), early HSC (multi-lineage potential), late HSC (lineage committed), and endothelial PCs (EPCs).ResultsBoth psychological stress and βAR-agonist infusion caused the expected mobilization of total monocytes and lymphocytes and CD8+ T lymphocytes. Psychological stress also induced a modest, but significant, increase in total PCs, HSCs, and EPC numbers in peripheral blood. However, infusion of a βAR-agonist did not result in a significant change in circulating PCs.ConclusionPCs are rapidly mobilized by psychological stress via mechanisms independent of βAR-stimulation, although the findings do not exclude βAR-stimulation as a possible cofactor. Considering the clinical and physiological relevance, further research into the mechanisms involved in stress-induced PC mobilization seems warranted.",
keywords = "Progenitor cells, Mobilization, Psychological stress, βAR-stimulation, Adrenergic",
author = "Natalie Riddell and Victoria Burns and Graham Wallace and Edwards, {Kate M} and Mark Drayson and Redwine, {Laura S} and Suzi Hong and Bui, {Jack C} and Fischer, {Johannes C} and Mills, {Paul J} and Jos Bosch",
year = "2015",
month = oct,
doi = "10.1016/j.bbi.2015.02.028",
language = "English",
volume = "49",
pages = "49--53",
journal = "Brain, Behaviour, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Progenitor cells are mobilized by acute physiological stress but not beta-adrenergic receptor agonist infusion

AU - Riddell, Natalie

AU - Burns, Victoria

AU - Wallace, Graham

AU - Edwards, Kate M

AU - Drayson, Mark

AU - Redwine, Laura S

AU - Hong, Suzi

AU - Bui, Jack C

AU - Fischer, Johannes C

AU - Mills, Paul J

AU - Bosch, Jos

PY - 2015/10

Y1 - 2015/10

N2 - ObjectivesStimuli that activate the sympathetic nervous system, such as acute psychological stress, rapidly invoke a robust mobilization of lymphocytes into the circulation. Experimental animal studies suggest that bone marrow-derived progenitor cells (PCs) also mobilize in response to sympathetic stimulation. Here we tested the effects of acute psychological stress and brief pharmacological β-adrenergic (βAR) stimulation on peripheral PC numbers in humans.MethodsIn two studies, we investigated PC mobilization in response to an acute speech task (n = 26) and βAR-agonist (isoproterenol) infusion (n = 20). A subset of 8 participants also underwent the infusion protocol with concomitant administration of the βAR-antagonist propranolol. Flow cytometry was used to enumerate lymphocyte subsets, total progenitor cells, total haematopoietic stem cells (HSC), early HSC (multi-lineage potential), late HSC (lineage committed), and endothelial PCs (EPCs).ResultsBoth psychological stress and βAR-agonist infusion caused the expected mobilization of total monocytes and lymphocytes and CD8+ T lymphocytes. Psychological stress also induced a modest, but significant, increase in total PCs, HSCs, and EPC numbers in peripheral blood. However, infusion of a βAR-agonist did not result in a significant change in circulating PCs.ConclusionPCs are rapidly mobilized by psychological stress via mechanisms independent of βAR-stimulation, although the findings do not exclude βAR-stimulation as a possible cofactor. Considering the clinical and physiological relevance, further research into the mechanisms involved in stress-induced PC mobilization seems warranted.

AB - ObjectivesStimuli that activate the sympathetic nervous system, such as acute psychological stress, rapidly invoke a robust mobilization of lymphocytes into the circulation. Experimental animal studies suggest that bone marrow-derived progenitor cells (PCs) also mobilize in response to sympathetic stimulation. Here we tested the effects of acute psychological stress and brief pharmacological β-adrenergic (βAR) stimulation on peripheral PC numbers in humans.MethodsIn two studies, we investigated PC mobilization in response to an acute speech task (n = 26) and βAR-agonist (isoproterenol) infusion (n = 20). A subset of 8 participants also underwent the infusion protocol with concomitant administration of the βAR-antagonist propranolol. Flow cytometry was used to enumerate lymphocyte subsets, total progenitor cells, total haematopoietic stem cells (HSC), early HSC (multi-lineage potential), late HSC (lineage committed), and endothelial PCs (EPCs).ResultsBoth psychological stress and βAR-agonist infusion caused the expected mobilization of total monocytes and lymphocytes and CD8+ T lymphocytes. Psychological stress also induced a modest, but significant, increase in total PCs, HSCs, and EPC numbers in peripheral blood. However, infusion of a βAR-agonist did not result in a significant change in circulating PCs.ConclusionPCs are rapidly mobilized by psychological stress via mechanisms independent of βAR-stimulation, although the findings do not exclude βAR-stimulation as a possible cofactor. Considering the clinical and physiological relevance, further research into the mechanisms involved in stress-induced PC mobilization seems warranted.

KW - Progenitor cells

KW - Mobilization

KW - Psychological stress

KW - βAR-stimulation

KW - Adrenergic

U2 - 10.1016/j.bbi.2015.02.028

DO - 10.1016/j.bbi.2015.02.028

M3 - Article

VL - 49

SP - 49

EP - 53

JO - Brain, Behaviour, and Immunity

JF - Brain, Behaviour, and Immunity

SN - 0889-1591

ER -