TY - JOUR
T1 - Profound hyperventilation and development of periodic breathing during exceptional orthostatic stress in a 21-year-old man
AU - Donnelly, J.
AU - Lucas, S.J.E.
AU - Thomas, K.N.
AU - Galvin, S.D.
AU - Ainslie, P.N.
PY - 2011/6/30
Y1 - 2011/6/30
N2 - In this case report we describe a trial of experimentally induced syncope in a healthy young volunteer that produced abnormal periods of hyperventilation (V̇A=57 L/min) and periodic breathing; the latter persisting for approximately 60. min following termination of the trial. In this example, independent of systemic hypotension, the severe hyperventilation and related hypocapnia (end-tidal PETCO2~5 mm Hg) induced by orthostatic stress (lower body negative pressure) resulted in a ~65% reduction in cerebral blood flow velocity. Potential mechanisms underlying these striking cardiorespiratory patterns are discussed.
AB - In this case report we describe a trial of experimentally induced syncope in a healthy young volunteer that produced abnormal periods of hyperventilation (V̇A=57 L/min) and periodic breathing; the latter persisting for approximately 60. min following termination of the trial. In this example, independent of systemic hypotension, the severe hyperventilation and related hypocapnia (end-tidal PETCO2~5 mm Hg) induced by orthostatic stress (lower body negative pressure) resulted in a ~65% reduction in cerebral blood flow velocity. Potential mechanisms underlying these striking cardiorespiratory patterns are discussed.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-79954906526&md5=fdbe044d0b55904c852065c7316f75c7
U2 - 10.1016/j.resp.2011.02.012
DO - 10.1016/j.resp.2011.02.012
M3 - Article
AN - SCOPUS:79954906526
SN - 1569-9048
VL - 177
SP - 66
EP - 70
JO - Respiratory physiology & neurobiology
JF - Respiratory physiology & neurobiology
IS - 1
ER -