Production of nanoparticles-in-microparticles by a double emulsion method : a comprehensive study

Yan Lee; Philip J. Johnson; Philip T. Robbins; Rachel H. Bridson

doi:10.1016/j.ejpb.2012.10.016

Production of nanoparticles-in-microparticles by a double emulsion method : a comprehensive study

Yan Lee, Philip J. Johnson, Philip T. Robbins, Rachel H. Bridson

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Abstract

A method based on a double emulsion system (solid-in-water-in-oil-in-water) has been developed for the production of nanoparticles-in-microparticles (NIMs). The distribution of nanoparticles within the NIMs was explored using light and electron microscopy and through assessment of drug loading and release profiles. The extent of nanoparticle entrapment within the NIMs was found to be dependent on the state (wet vs. dry) in which the nanoparticles were introduced to the formulation. The technique was readily adaptable to produce NIMs of different morphologies. It is proposed that NIMs and this method to produce them have broad application in drug delivery research.

Original language	English
Pages (from-to)	168-173
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	83
Issue number	2
Early online date	12 Nov 2012
DOIs	https://doi.org/10.1016/j.ejpb.2012.10.016
Publication status	Published - 1 Feb 2013

Keywords

Nanoparticles-in-microparticles
Solid-in-water-in-oil-water emulsion
Drug delivery
PLGA
PCL
Solvent evaporation

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10.1016/j.ejpb.2012.10.016

Lee_Production_nanoparticles_EJPB_2013
Eligibility for repository : checked 13/03/2014
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Production & Evaluation of Microparticulate Drug Delivery System to Enhance Aterial Chemoembolization
Bridson, R. & Johnson, P.
Engineering & Physical Science Research Council
3/08/09 → 2/08/12
Project: Research Councils

Cite this

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title = "Production of nanoparticles-in-microparticles by a double emulsion method : a comprehensive study",

abstract = "A method based on a double emulsion system (solid-in-water-in-oil-in-water) has been developed for the production of nanoparticles-in-microparticles (NIMs). The distribution of nanoparticles within the NIMs was explored using light and electron microscopy and through assessment of drug loading and release profiles. The extent of nanoparticle entrapment within the NIMs was found to be dependent on the state (wet vs. dry) in which the nanoparticles were introduced to the formulation. The technique was readily adaptable to produce NIMs of different morphologies. It is proposed that NIMs and this method to produce them have broad application in drug delivery research.",

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AU - Robbins, Philip T.

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AB - A method based on a double emulsion system (solid-in-water-in-oil-in-water) has been developed for the production of nanoparticles-in-microparticles (NIMs). The distribution of nanoparticles within the NIMs was explored using light and electron microscopy and through assessment of drug loading and release profiles. The extent of nanoparticle entrapment within the NIMs was found to be dependent on the state (wet vs. dry) in which the nanoparticles were introduced to the formulation. The technique was readily adaptable to produce NIMs of different morphologies. It is proposed that NIMs and this method to produce them have broad application in drug delivery research.

KW - Nanoparticles-in-microparticles

KW - Solid-in-water-in-oil-water emulsion

KW - Drug delivery

KW - PLGA

KW - PCL

KW - Solvent evaporation

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JF - European Journal of Pharmaceutics and Biopharmaceutics

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Production of nanoparticles-in-microparticles by a double emulsion method : a comprehensive study

Abstract

Keywords

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Production & Evaluation of Microparticulate Drug Delivery System to Enhance Aterial Chemoembolization

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