Probing and tuning the permeability of polymersomes

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Probing and tuning the permeability of polymersomes. / Miller, Alisha J.; Pearce, Amanda K.; Foster, Jeffrey C.; O'Reilly, Rachel K.

In: ACS Central Science, Vol. 7, No. 1, 27.01.2021, p. 30-38.

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@article{e8675f7d68b84e2eada335770bcc43ea,
title = "Probing and tuning the permeability of polymersomes",
abstract = "Polymersomes are a class of synthetic vesicles composed of a polymer membrane surrounding an aqueous inner cavity. In addition to their overall size, the thickness and composition of polymersome membranes determine the range of potential applications in which they can be employed. While synthetic polymer chemists have made great strides in controlling polymersome membrane parameters, measurement of their permeability to various analytes including gases, ions, organic molecules, and macromolecules remains a significant challenge. In this Outlook, we compare the general methods that have been developed to quantify polymersome membrane permeability, focusing in particular on their capability to accurately measure analyte flux. In addition, we briefly highlight strategies to control membrane permeability. Based on these learnings, we propose a set of criteria for designing future methods of quantifying membrane permeability such that the passage of a variety of molecules into and out of their lumens can be better understood. ",
author = "Miller, {Alisha J.} and Pearce, {Amanda K.} and Foster, {Jeffrey C.} and O'Reilly, {Rachel K.}",
note = "Funding Information: This work was supported by the ERC (Grant 615142), EPSRC, and the University of Birmingham.",
year = "2021",
month = jan,
day = "27",
doi = "10.1021/acscentsci.0c01196",
language = "English",
volume = "7",
pages = "30--38",
journal = "ACS Central Science",
issn = "2374-7951",
publisher = "American Chemical Society",
number = "1",

}

RIS

TY - JOUR

T1 - Probing and tuning the permeability of polymersomes

AU - Miller, Alisha J.

AU - Pearce, Amanda K.

AU - Foster, Jeffrey C.

AU - O'Reilly, Rachel K.

N1 - Funding Information: This work was supported by the ERC (Grant 615142), EPSRC, and the University of Birmingham.

PY - 2021/1/27

Y1 - 2021/1/27

N2 - Polymersomes are a class of synthetic vesicles composed of a polymer membrane surrounding an aqueous inner cavity. In addition to their overall size, the thickness and composition of polymersome membranes determine the range of potential applications in which they can be employed. While synthetic polymer chemists have made great strides in controlling polymersome membrane parameters, measurement of their permeability to various analytes including gases, ions, organic molecules, and macromolecules remains a significant challenge. In this Outlook, we compare the general methods that have been developed to quantify polymersome membrane permeability, focusing in particular on their capability to accurately measure analyte flux. In addition, we briefly highlight strategies to control membrane permeability. Based on these learnings, we propose a set of criteria for designing future methods of quantifying membrane permeability such that the passage of a variety of molecules into and out of their lumens can be better understood.

AB - Polymersomes are a class of synthetic vesicles composed of a polymer membrane surrounding an aqueous inner cavity. In addition to their overall size, the thickness and composition of polymersome membranes determine the range of potential applications in which they can be employed. While synthetic polymer chemists have made great strides in controlling polymersome membrane parameters, measurement of their permeability to various analytes including gases, ions, organic molecules, and macromolecules remains a significant challenge. In this Outlook, we compare the general methods that have been developed to quantify polymersome membrane permeability, focusing in particular on their capability to accurately measure analyte flux. In addition, we briefly highlight strategies to control membrane permeability. Based on these learnings, we propose a set of criteria for designing future methods of quantifying membrane permeability such that the passage of a variety of molecules into and out of their lumens can be better understood.

UR - http://www.scopus.com/inward/record.url?scp=85098934987&partnerID=8YFLogxK

U2 - 10.1021/acscentsci.0c01196

DO - 10.1021/acscentsci.0c01196

M3 - Article

C2 - 33532567

AN - SCOPUS:85098934987

VL - 7

SP - 30

EP - 38

JO - ACS Central Science

JF - ACS Central Science

SN - 2374-7951

IS - 1

ER -