TY - JOUR
T1 - Prior tuberculosis, smoking and airflow obstruction
T2 - a cross-sectional analysis of the Guangzhou Biobank Cohort Study
AU - Lam, Kin Bong Hubert
AU - Jiang, CQ
AU - Jordan, Rachel
AU - Miller, Martin
AU - Zhang, Wei
AU - Cheng, Kar
AU - Lam, T
AU - Adab, Peymane
PY - 2010/3/1
Y1 - 2010/3/1
N2 - BACKGROUND: Prior pulmonary tuberculosis (TB) has been shown to be associated with higher risk of airflow obstruction, the hallmark of chronic obstructive pulmonary disease (COPD), but whether smoking modifies this relationship is unclear. We investigated the relationships between prior TB, smoking and airflow obstruction in a Chinese population sample. METHODS: Participants in the Guangzhou Biobank Cohort Study underwent spirometry, chest radiography and a structured interview on lifestyle and exposures. Prior TB was defined as the presence of radiographic evidence suggestive of inactive TB. Airflow obstruction was based on spirometric criteria. RESULTS: The prevalence of prior TB in this sample (N=8,066, mean age: 61.9 years) was 24.2%. After controlling for sex, age, and smoking exposure, prior TB remained independently associated with increased risk of airflow obstruction (OR=1.37; 95% CI 1.13-1.67). Further adjustment for exposure to passive smoking, biomass fuel and dust did not alter the relationship. Smoking did not modify the relationship between prior TB and airflow obstruction. CONCLUSIONS: Prior TB is an independent risk factor for airflow obstruction, which may partly explain the higher prevalence of COPD in China. Clinicians should be aware of this long term risk in individuals with prior TB, irrespective of smoking status, particularly in patients from countries with high TB burden.
AB - BACKGROUND: Prior pulmonary tuberculosis (TB) has been shown to be associated with higher risk of airflow obstruction, the hallmark of chronic obstructive pulmonary disease (COPD), but whether smoking modifies this relationship is unclear. We investigated the relationships between prior TB, smoking and airflow obstruction in a Chinese population sample. METHODS: Participants in the Guangzhou Biobank Cohort Study underwent spirometry, chest radiography and a structured interview on lifestyle and exposures. Prior TB was defined as the presence of radiographic evidence suggestive of inactive TB. Airflow obstruction was based on spirometric criteria. RESULTS: The prevalence of prior TB in this sample (N=8,066, mean age: 61.9 years) was 24.2%. After controlling for sex, age, and smoking exposure, prior TB remained independently associated with increased risk of airflow obstruction (OR=1.37; 95% CI 1.13-1.67). Further adjustment for exposure to passive smoking, biomass fuel and dust did not alter the relationship. Smoking did not modify the relationship between prior TB and airflow obstruction. CONCLUSIONS: Prior TB is an independent risk factor for airflow obstruction, which may partly explain the higher prevalence of COPD in China. Clinicians should be aware of this long term risk in individuals with prior TB, irrespective of smoking status, particularly in patients from countries with high TB burden.
KW - Napping
KW - impaired fasting glucose
KW - Chinese
KW - type 2 diabetes
UR - http://europepmc.org/abstract/med/19820078
U2 - 10.1378/chest.09-1435
DO - 10.1378/chest.09-1435
M3 - Article
C2 - 19820078
VL - 137
SP - 593
EP - 600
JO - Chest
JF - Chest
IS - 3
ER -