Projects per year
Abstract
Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.
Original language | English |
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Pages (from-to) | 849-54 |
Number of pages | 6 |
Journal | Journal of viral hepatitis |
Volume | 15 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2008 |
Keywords
- lipoproteins
- receptors
- hepatocyte
- internalization
- hepatitis C
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Dive into the research topics of 'Primary hepatocytes as targets for hepatitis C virus replication.'. Together they form a unique fingerprint.Projects
- 1 Finished
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Mechanisms of Hepatitis C Virus Induced Hepatocyte Injury
McKeating, J. & Balfe, P.
1/10/09 → 30/09/12
Project: Research Councils