Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks

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Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks. / Shen, Songying; Xiao, Wanqing; Zhang, Lifang; Lu, Jinhua; Funk, Anna ; He, Jianrong; Tu, Si ; Yu, Jia ; Yang, Li; Fontanet, Arnaud ; Bao, Wei ; Cheng, KK; Qiu, Xiu.

In: BMC pregnancy and childbirth, Vol. 21, 214, 17.03.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Shen, S, Xiao, W, Zhang, L, Lu, J, Funk, A, He, J, Tu, S, Yu, J, Yang, L, Fontanet, A, Bao, W, Cheng, KK & Qiu, X 2021, 'Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks', BMC pregnancy and childbirth, vol. 21, 214. https://doi.org/10.1186/s12884-021-03705-9

APA

Shen, S., Xiao, W., Zhang, L., Lu, J., Funk, A., He, J., Tu, S., Yu, J., Yang, L., Fontanet, A., Bao, W., Cheng, KK., & Qiu, X. (2021). Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks. BMC pregnancy and childbirth, 21, [214]. https://doi.org/10.1186/s12884-021-03705-9

Vancouver

Author

Shen, Songying ; Xiao, Wanqing ; Zhang, Lifang ; Lu, Jinhua ; Funk, Anna ; He, Jianrong ; Tu, Si ; Yu, Jia ; Yang, Li ; Fontanet, Arnaud ; Bao, Wei ; Cheng, KK ; Qiu, Xiu. / Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks. In: BMC pregnancy and childbirth. 2021 ; Vol. 21.

Bibtex

@article{b0c172aa6bc141f1b3b4596bc468dbac,
title = "Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks",
abstract = "Background: Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak.Methods: This study included singletons born after 24 gestational weeks in 2017–2018 at four hospitals in Guangzhou, China. Microcephaly was defined as a head circumference at birth >3SD below the mean for sex and gestational age. Prevalence of microcephaly was estimated by binomial exact method. Multivariable logistic regression was used to examine the associations of microcephaly with prenatal factors. The population attributable fraction (PAF) for associated risk factors was calculated.Results: Of 46,610 live births included, 154 (3.3, 95% CI 2.8–3.9 per 1000 live births) microcephalies were identified. Maternal hepatitis B virus carriers (HBV, OR 1.80, 95% CI 1.05–3.10) and primipara (OR 2.68, 95% CI 1.89–3.81) had higher risk of having a microcephalic baby. Higher prevalence of microcephaly was observed in women who had premature labor (OR 1.98, 95% CI 1.17–3.34) and had a baby with fetal growth restriction (OR 16.38, 95% CI 11.81–22.71). Four identified factors (HBV, primiparity, preterm labor, and fetal growth restriction) contributed to 66.4% of the risk of microcephaly.Conclusions: The prevalence of microcephaly in Guangzhou was higher than expected. This study identified four prenatal risk factors that, together, contributed to two-thirds of the increased risk of microcephaly. This is the first reported association between maternal HBV carrier status and microcephaly.",
author = "Songying Shen and Wanqing Xiao and Lifang Zhang and Jinhua Lu and Anna Funk and Jianrong He and Si Tu and Jia Yu and Li Yang and Arnaud Fontanet and Wei Bao and KK Cheng and Xiu Qiu",
year = "2021",
month = mar,
day = "17",
doi = "10.1186/s12884-021-03705-9",
language = "English",
volume = "21",
journal = "BMC pregnancy and childbirth",
issn = "1471-2393",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks

AU - Shen, Songying

AU - Xiao, Wanqing

AU - Zhang, Lifang

AU - Lu, Jinhua

AU - Funk, Anna

AU - He, Jianrong

AU - Tu, Si

AU - Yu, Jia

AU - Yang, Li

AU - Fontanet, Arnaud

AU - Bao, Wei

AU - Cheng, KK

AU - Qiu, Xiu

PY - 2021/3/17

Y1 - 2021/3/17

N2 - Background: Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak.Methods: This study included singletons born after 24 gestational weeks in 2017–2018 at four hospitals in Guangzhou, China. Microcephaly was defined as a head circumference at birth >3SD below the mean for sex and gestational age. Prevalence of microcephaly was estimated by binomial exact method. Multivariable logistic regression was used to examine the associations of microcephaly with prenatal factors. The population attributable fraction (PAF) for associated risk factors was calculated.Results: Of 46,610 live births included, 154 (3.3, 95% CI 2.8–3.9 per 1000 live births) microcephalies were identified. Maternal hepatitis B virus carriers (HBV, OR 1.80, 95% CI 1.05–3.10) and primipara (OR 2.68, 95% CI 1.89–3.81) had higher risk of having a microcephalic baby. Higher prevalence of microcephaly was observed in women who had premature labor (OR 1.98, 95% CI 1.17–3.34) and had a baby with fetal growth restriction (OR 16.38, 95% CI 11.81–22.71). Four identified factors (HBV, primiparity, preterm labor, and fetal growth restriction) contributed to 66.4% of the risk of microcephaly.Conclusions: The prevalence of microcephaly in Guangzhou was higher than expected. This study identified four prenatal risk factors that, together, contributed to two-thirds of the increased risk of microcephaly. This is the first reported association between maternal HBV carrier status and microcephaly.

AB - Background: Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak.Methods: This study included singletons born after 24 gestational weeks in 2017–2018 at four hospitals in Guangzhou, China. Microcephaly was defined as a head circumference at birth >3SD below the mean for sex and gestational age. Prevalence of microcephaly was estimated by binomial exact method. Multivariable logistic regression was used to examine the associations of microcephaly with prenatal factors. The population attributable fraction (PAF) for associated risk factors was calculated.Results: Of 46,610 live births included, 154 (3.3, 95% CI 2.8–3.9 per 1000 live births) microcephalies were identified. Maternal hepatitis B virus carriers (HBV, OR 1.80, 95% CI 1.05–3.10) and primipara (OR 2.68, 95% CI 1.89–3.81) had higher risk of having a microcephalic baby. Higher prevalence of microcephaly was observed in women who had premature labor (OR 1.98, 95% CI 1.17–3.34) and had a baby with fetal growth restriction (OR 16.38, 95% CI 11.81–22.71). Four identified factors (HBV, primiparity, preterm labor, and fetal growth restriction) contributed to 66.4% of the risk of microcephaly.Conclusions: The prevalence of microcephaly in Guangzhou was higher than expected. This study identified four prenatal risk factors that, together, contributed to two-thirds of the increased risk of microcephaly. This is the first reported association between maternal HBV carrier status and microcephaly.

U2 - 10.1186/s12884-021-03705-9

DO - 10.1186/s12884-021-03705-9

M3 - Article

VL - 21

JO - BMC pregnancy and childbirth

JF - BMC pregnancy and childbirth

SN - 1471-2393

M1 - 214

ER -