Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2

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Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2. / Liljegren, A; Barker, G; Elliott, F; Bertario, L; Bisgaard, ML; Eccles, D; Evans, G; Macrae, F; Maher, Eamonn; Lindblom, A; Rotstein, S; Nilsson, B; Mecklin, JP; Moeslein, G; Jass, J; Fodde, R; Mathers, Jonathan; Burn, J; Bishop, DT.

In: Journal of Clinical Oncology, Vol. 26, No. 20, 01.07.2008, p. 3434-3439.

Research output: Contribution to journalArticle

Harvard

Liljegren, A, Barker, G, Elliott, F, Bertario, L, Bisgaard, ML, Eccles, D, Evans, G, Macrae, F, Maher, E, Lindblom, A, Rotstein, S, Nilsson, B, Mecklin, JP, Moeslein, G, Jass, J, Fodde, R, Mathers, J, Burn, J & Bishop, DT 2008, 'Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2', Journal of Clinical Oncology, vol. 26, no. 20, pp. 3434-3439. https://doi.org/10.1200/JCO.2007.13.2795

APA

Liljegren, A., Barker, G., Elliott, F., Bertario, L., Bisgaard, ML., Eccles, D., Evans, G., Macrae, F., Maher, E., Lindblom, A., Rotstein, S., Nilsson, B., Mecklin, JP., Moeslein, G., Jass, J., Fodde, R., Mathers, J., Burn, J., & Bishop, DT. (2008). Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2. Journal of Clinical Oncology, 26(20), 3434-3439. https://doi.org/10.1200/JCO.2007.13.2795

Vancouver

Author

Liljegren, A ; Barker, G ; Elliott, F ; Bertario, L ; Bisgaard, ML ; Eccles, D ; Evans, G ; Macrae, F ; Maher, Eamonn ; Lindblom, A ; Rotstein, S ; Nilsson, B ; Mecklin, JP ; Moeslein, G ; Jass, J ; Fodde, R ; Mathers, Jonathan ; Burn, J ; Bishop, DT. / Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2. In: Journal of Clinical Oncology. 2008 ; Vol. 26, No. 20. pp. 3434-3439.

Bibtex

@article{0aece23708d24ca8bfb16869a468a74d,
title = "Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2",
abstract = "Purpose To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. Patients and Methods Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. Results Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. Conclusion Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.",
author = "A Liljegren and G Barker and F Elliott and L Bertario and ML Bisgaard and D Eccles and G Evans and F Macrae and Eamonn Maher and A Lindblom and S Rotstein and B Nilsson and JP Mecklin and G Moeslein and J Jass and R Fodde and Jonathan Mathers and J Burn and DT Bishop",
year = "2008",
month = jul,
day = "1",
doi = "10.1200/JCO.2007.13.2795",
language = "English",
volume = "26",
pages = "3434--3439",
journal = "Journal of Clinical Oncology ",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "20",

}

RIS

TY - JOUR

T1 - Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2

AU - Liljegren, A

AU - Barker, G

AU - Elliott, F

AU - Bertario, L

AU - Bisgaard, ML

AU - Eccles, D

AU - Evans, G

AU - Macrae, F

AU - Maher, Eamonn

AU - Lindblom, A

AU - Rotstein, S

AU - Nilsson, B

AU - Mecklin, JP

AU - Moeslein, G

AU - Jass, J

AU - Fodde, R

AU - Mathers, Jonathan

AU - Burn, J

AU - Bishop, DT

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Purpose To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. Patients and Methods Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. Results Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. Conclusion Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.

AB - Purpose To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC). These prevalences have been estimated previously in smaller studies, and the results have been found to be variable. Patients and Methods Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC. The 695 patients with a proven germline MMR mutation and documented screening history before the chemoprevention study were the focus of this study. The number, histology, size, and location of polyps found at the participants' first ever colonoscopy were analyzed in a cross-sectional study. Results Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp. The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend). No such trend was observed for hyperplastic polyps. No sex differences were found for either type of polyp. A marginal association was found between the co-occurrence of adenomas and hyperplastic polyps. Adenomas tended to be more proximally distributed through the colon, whereas hyperplastic polyps tended to be located in the distal colon. Conclusion Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent. No sex differences were observed for either type of lesion.

U2 - 10.1200/JCO.2007.13.2795

DO - 10.1200/JCO.2007.13.2795

M3 - Article

C2 - 18612159

VL - 26

SP - 3434

EP - 3439

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 20

ER -