Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation

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Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation. / Cox, Sophie C.; Jamshidi, Parastoo; Grover, Liam M.; Mallick, Kajal K.

In: Materials Science and Engineering C, Vol. 35, No. 1, 2014, p. 106-114.

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@article{178eabf18e9d4dde90384379e1d44a8c,
title = "Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation",
abstract = "Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20 C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture.",
keywords = "Aqueous precipitation, Bioceramics, Osteoblasts, Simulated body fluid, Substituted hydroxyapatite",
author = "Cox, {Sophie C.} and Parastoo Jamshidi and Grover, {Liam M.} and Mallick, {Kajal K.}",
year = "2014",
doi = "10.1016/j.msec.2013.10.015",
language = "English",
volume = "35",
pages = "106--114",
journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Preparation and characterisation of nanophase Sr, Mg, and Zn substituted hydroxyapatite by aqueous precipitation

AU - Cox, Sophie C.

AU - Jamshidi, Parastoo

AU - Grover, Liam M.

AU - Mallick, Kajal K.

PY - 2014

Y1 - 2014

N2 - Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20 C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture.

AB - Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20 C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture.

KW - Aqueous precipitation

KW - Bioceramics

KW - Osteoblasts

KW - Simulated body fluid

KW - Substituted hydroxyapatite

UR - http://www.scopus.com/inward/record.url?scp=84888215560&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2013.10.015

DO - 10.1016/j.msec.2013.10.015

M3 - Article

C2 - 24411358

AN - SCOPUS:84888215560

VL - 35

SP - 106

EP - 114

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

SN - 0928-4931

IS - 1

ER -