Premature coronary artery disease and early stage chronic kidney disease

A M Price; C J Ferro; M K Hayer; R P Steeds; N C Edwards; J N Townend

doi:10.1093/qjmed/hcx179

Premature coronary artery disease and early stage chronic kidney disease

A M Price, C J Ferro, M K Hayer, R P Steeds, N C Edwards, J N Townend

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Abstract

A 30 year old asymptomatic male with stage 3 chronic kidney disease (CKD) secondary to Focal Segmental Glomerulosclerosis was found to have features of CKD associated cardiomyopathy including left ventricular hypertrophy (LVH) and focal subendocardial scarring on cardiac magnetic resonance imaging. There was also a significantly raised CT coronary calcium score and evidence of non-flow limiting coronary artery disease (CAD) on a CT coronary angiogram. Early stage CKD is a major risk factor for cardiovascular risk causing myocardial hypertrophy and fibrosis and coronary artery atheroma. Cardiovascular risk begins to
increase from an eGFR of around 75ml/min/1.73m2. The pathophysiology of cardiovascular disease in CKD is under investigation but to date, treatment options are limited. Blood pressure control and statins have the strongest supportive evidence.

Original language	English
Pages (from-to)	683–686
Journal	QJM: An International Journal of Medicine
Volume	111
Issue number	10
DOIs	https://doi.org/10.1093/qjmed/hcx179
Publication status	Published - 18 Sept 2017

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10.1093/qjmed/hcx179Licence: Creative Commons: Attribution (CC BY)

Price_et_al_2017_Premature_coronary_artery_disease_QJMFinal published version, 147 KBLicence: Creative Commons: Attribution (CC BY)

http://academic.oup.com/qjmed/article/doi/10.1093/qjmed/hcx179/4161097/Premature-coronary-artery-disease-and-early-stage

Onset and Functional Consequences of Left Ventricular Fibrosis in Chronic Kidney Disease
Edwards, N. & Steeds, R.
British Heart Foundation
3/08/16 → 2/02/19
Project: Research
The Effects of a Modest Reduction in Renal Function on Cardiovascular Structure and Function: A Study of Kidney Donors
Townend, J., Ferro, C., Madhani, M., Marshall, J. & Moody, W.
British Heart Foundation
1/04/11 → 31/03/14
Project: Research

Cite this

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title = "Premature coronary artery disease and early stage chronic kidney disease",

abstract = "A 30 year old asymptomatic male with stage 3 chronic kidney disease (CKD) secondary to Focal Segmental Glomerulosclerosis was found to have features of CKD associated cardiomyopathy including left ventricular hypertrophy (LVH) and focal subendocardial scarring on cardiac magnetic resonance imaging. There was also a significantly raised CT coronary calcium score and evidence of non-flow limiting coronary artery disease (CAD) on a CT coronary angiogram. Early stage CKD is a major risk factor for cardiovascular risk causing myocardial hypertrophy and fibrosis and coronary artery atheroma. Cardiovascular risk begins toincrease from an eGFR of around 75ml/min/1.73m2. The pathophysiology of cardiovascular disease in CKD is under investigation but to date, treatment options are limited. Blood pressure control and statins have the strongest supportive evidence.",

author = "Price, {A M} and Ferro, {C J} and Hayer, {M K} and Steeds, {R P} and Edwards, {N C} and Townend, {J N}",

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doi = "10.1093/qjmed/hcx179",

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T1 - Premature coronary artery disease and early stage chronic kidney disease

AU - Price, A M

AU - Ferro, C J

AU - Hayer, M K

AU - Steeds, R P

AU - Edwards, N C

AU - Townend, J N

PY - 2017/9/18

Y1 - 2017/9/18

N2 - A 30 year old asymptomatic male with stage 3 chronic kidney disease (CKD) secondary to Focal Segmental Glomerulosclerosis was found to have features of CKD associated cardiomyopathy including left ventricular hypertrophy (LVH) and focal subendocardial scarring on cardiac magnetic resonance imaging. There was also a significantly raised CT coronary calcium score and evidence of non-flow limiting coronary artery disease (CAD) on a CT coronary angiogram. Early stage CKD is a major risk factor for cardiovascular risk causing myocardial hypertrophy and fibrosis and coronary artery atheroma. Cardiovascular risk begins toincrease from an eGFR of around 75ml/min/1.73m2. The pathophysiology of cardiovascular disease in CKD is under investigation but to date, treatment options are limited. Blood pressure control and statins have the strongest supportive evidence.

AB - A 30 year old asymptomatic male with stage 3 chronic kidney disease (CKD) secondary to Focal Segmental Glomerulosclerosis was found to have features of CKD associated cardiomyopathy including left ventricular hypertrophy (LVH) and focal subendocardial scarring on cardiac magnetic resonance imaging. There was also a significantly raised CT coronary calcium score and evidence of non-flow limiting coronary artery disease (CAD) on a CT coronary angiogram. Early stage CKD is a major risk factor for cardiovascular risk causing myocardial hypertrophy and fibrosis and coronary artery atheroma. Cardiovascular risk begins toincrease from an eGFR of around 75ml/min/1.73m2. The pathophysiology of cardiovascular disease in CKD is under investigation but to date, treatment options are limited. Blood pressure control and statins have the strongest supportive evidence.

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DO - 10.1093/qjmed/hcx179

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SN - 1460-2725

VL - 111

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EP - 686

JO - QJM: An International Journal of Medicine

JF - QJM: An International Journal of Medicine

IS - 10

ER -

Premature coronary artery disease and early stage chronic kidney disease

Abstract

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Projects

Onset and Functional Consequences of Left Ventricular Fibrosis in Chronic Kidney Disease

The Effects of a Modest Reduction in Renal Function on Cardiovascular Structure and Function: A Study of Kidney Donors

Cite this