TY - JOUR
T1 - Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens
AU - Rahman, F
AU - Manchanda, R
AU - Brain, Keith
PY - 2009/6/15
Y1 - 2009/6/15
N2 - Heptanol and 18 beta-glycyrrhetinic acid (18 beta GA) block gap junctions, but have other actions on transmitter release that have not been characterised. This study investigates the prejunctional and postjunctional effects of these compounds in guinea pig and mouse vas deferens using intracellular electrophysiological recording and confocal Ca(2+) imaging of sympathetic nerve terminals. In mice, heptanol (2 mM) reversibly decreased the amplitude of purinergic excitatory junction potentials (EJPs; 52+/-5%, P
AB - Heptanol and 18 beta-glycyrrhetinic acid (18 beta GA) block gap junctions, but have other actions on transmitter release that have not been characterised. This study investigates the prejunctional and postjunctional effects of these compounds in guinea pig and mouse vas deferens using intracellular electrophysiological recording and confocal Ca(2+) imaging of sympathetic nerve terminals. In mice, heptanol (2 mM) reversibly decreased the amplitude of purinergic excitatory junction potentials (EJPs; 52+/-5%, P
U2 - 10.1016/j.autneu.2009.03.006
DO - 10.1016/j.autneu.2009.03.006
M3 - Article
C2 - 19375392
VL - 148
SP - 69
EP - 75
JO - Autonomic Neuroscience
JF - Autonomic Neuroscience
IS - 1-2
ER -