Prejunctional and postjunctional actions of heptanol and 18β-glycyrretinic acid in the rodent vas deferens
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
Heptanol and 18 beta-glycyrrhetinic acid (18 beta GA) block gap junctions, but have other actions on transmitter release that have not been characterised. This study investigates the prejunctional and postjunctional effects of these compounds in guinea pig and mouse vas deferens using intracellular electrophysiological recording and confocal Ca(2+) imaging of sympathetic nerve terminals. In mice, heptanol (2 mM) reversibly decreased the amplitude of purinergic excitatory junction potentials (EJPs; 52+/-5%, P
Details
| Original language | English |
|---|---|
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| Journal | Autonomic Neuroscience |
| Volume | 148 |
| Issue number | 1-2 |
| Publication status | Published - 15 Jun 2009 |