TY - JOUR
T1 - Prediction of Survival Among Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma
T2 - A Response-Based Approach
AU - Han, Guohong
AU - Berhane, Sarah
AU - Toyoda, Hidenori
AU - Bettinger, Dominik
AU - Elshaarawy, Omar
AU - Chan, Anthony W H
AU - Kirstein, Martha
AU - Mosconi, Cristina
AU - Hucke, Florian
AU - Palmer, Daniel
AU - Pinato, David J
AU - Sharma, Rohini
AU - Ottaviani, Diego
AU - Jang, Jeong W
AU - Labeur, Tim A
AU - van Delden, Otto M
AU - Pirisi, Mario
AU - Stern, Nick
AU - Sangro, Bruno
AU - Meyer, Tim
AU - Fateen, Waleed
AU - García-Fiñana, Marta
AU - Gomaa, Asmaa
AU - Waked, Imam
AU - Rewisha, Eman
AU - Aithal, Guru P
AU - Travis, Simon
AU - Kudo, Masatoshi
AU - Cucchetti, Alessandro
AU - Peck-Radosavljevic, Markus
AU - Takkenberg, R B
AU - Chan, Stephen L
AU - Vogel, Arndt
AU - Johnson, Philip J
N1 - © 2020 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.
PY - 2020/7
Y1 - 2020/7
N2 - BACKGROUND AND AIMS: The heterogeneity of intermediate-stage hepatocellular carcinoma (HCC) and the widespread use of transarterial chemoembolization (TACE) outside recommended guidelines have encouraged the development of scoring systems that predict patient survival. The aim of this study was to build and validate statistical models that offer individualized patient survival prediction using response to TACE as a variable.APPROACH AND RESULTS: Clinically relevant baseline parameters were collected for 4,621 patients with HCC treated with TACE at 19 centers in 11 countries. In some of the centers, radiological responses (as assessed by modified Response Evaluation Criteria in Solid Tumors [mRECIST]) were also accrued. The data set was divided into a training set, an internal validation set, and two external validation sets. A pre-TACE model ("Pre-TACE-Predict") and a post-TACE model ("Post-TACE-Predict") that included response were built. The performance of the models in predicting overall survival (OS) was compared with existing ones. The median OS was 19.9 months. The factors influencing survival were tumor number and size, alpha-fetoprotein, albumin, bilirubin, vascular invasion, cause, and response as assessed by mRECIST. The proposed models showed superior predictive accuracy compared with existing models (the hepatoma arterial embolization prognostic score and its various modifications) and allowed for patient stratification into four distinct risk categories whose median OS ranged from 7 months to more than 4 years.CONCLUSIONS: A TACE-specific and extensively validated model based on routinely available clinical features and response after first TACE permitted patient-level prognostication.
AB - BACKGROUND AND AIMS: The heterogeneity of intermediate-stage hepatocellular carcinoma (HCC) and the widespread use of transarterial chemoembolization (TACE) outside recommended guidelines have encouraged the development of scoring systems that predict patient survival. The aim of this study was to build and validate statistical models that offer individualized patient survival prediction using response to TACE as a variable.APPROACH AND RESULTS: Clinically relevant baseline parameters were collected for 4,621 patients with HCC treated with TACE at 19 centers in 11 countries. In some of the centers, radiological responses (as assessed by modified Response Evaluation Criteria in Solid Tumors [mRECIST]) were also accrued. The data set was divided into a training set, an internal validation set, and two external validation sets. A pre-TACE model ("Pre-TACE-Predict") and a post-TACE model ("Post-TACE-Predict") that included response were built. The performance of the models in predicting overall survival (OS) was compared with existing ones. The median OS was 19.9 months. The factors influencing survival were tumor number and size, alpha-fetoprotein, albumin, bilirubin, vascular invasion, cause, and response as assessed by mRECIST. The proposed models showed superior predictive accuracy compared with existing models (the hepatoma arterial embolization prognostic score and its various modifications) and allowed for patient stratification into four distinct risk categories whose median OS ranged from 7 months to more than 4 years.CONCLUSIONS: A TACE-specific and extensively validated model based on routinely available clinical features and response after first TACE permitted patient-level prognostication.
UR - http://www.scopus.com/inward/record.url?scp=85085573080&partnerID=8YFLogxK
U2 - 10.1002/hep.31022
DO - 10.1002/hep.31022
M3 - Article
C2 - 31698504
SN - 0270-9139
VL - 72
SP - 198
EP - 212
JO - Hepatology
JF - Hepatology
IS - 1
ER -