Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

Research output: Contribution to journalArticlepeer-review

Standard

Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy. / Proix, Timothée; Bartolomei, Fabrice; Guye, Maxime; Truccolo, Wilson; Jirsa, Viktor.

In: Nature Communications, Vol. 9, 1088, 14.03.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Proix, Timothée ; Bartolomei, Fabrice ; Guye, Maxime ; Truccolo, Wilson ; Jirsa, Viktor. / Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy. In: Nature Communications. 2018 ; Vol. 9.

Bibtex

@article{e255c9ce4bf641e0951d35d6af8bc761,
title = "Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy",
abstract = "Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.",
keywords = "Brain/pathology, Electroencephalography, Epilepsies, Partial/pathology, Humans, Seizures/pathology",
author = "Timoth{\'e}e Proix and Fabrice Bartolomei and Maxime Guye and Wilson Truccolo and Viktor Jirsa",
year = "2018",
month = mar,
day = "14",
doi = "10.1038/s41467-018-02973-y",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

AU - Proix, Timothée

AU - Bartolomei, Fabrice

AU - Guye, Maxime

AU - Truccolo, Wilson

AU - Jirsa, Viktor

PY - 2018/3/14

Y1 - 2018/3/14

N2 - Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.

AB - Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.

KW - Brain/pathology

KW - Electroencephalography

KW - Epilepsies, Partial/pathology

KW - Humans

KW - Seizures/pathology

U2 - 10.1038/s41467-018-02973-y

DO - 10.1038/s41467-018-02973-y

M3 - Article

C2 - 29540685

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 1088

ER -