Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

Research output: Contribution to journalArticlepeer-review

Authors

  • Timothée Proix
  • Fabrice Bartolomei
  • Maxime Guye
  • Wilson Truccolo
  • Viktor Jirsa

Colleges, School and Institutes

External organisations

  • Brown University
  • Institut de Neurosciences des Systèmes (INS)
  • CNRS, Écologie des Forêts de Guyane (UMR-CNRS 8172)

Abstract

Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillator dynamics, together with the interaction of multiple time scales, account for the reported diversity. We confirm our predictions in seizures and tractography data obtained from patients with pharmacologically resistant epilepsy. Our results contribute toward patient-specific seizure modeling.

Details

Original languageEnglish
Article number1088
JournalNature Communications
Volume9
Publication statusPublished - 14 Mar 2018

Keywords

  • Brain/pathology, Electroencephalography, Epilepsies, Partial/pathology, Humans, Seizures/pathology