Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
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Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. / Darby, Matthew G.; Chetty, Alisha; Mrjden, Dunja; Rolot, Marion; Smith, Katherine; MacKowiak, Claire; Sedda, Delphine; Nyangahu, Donald; Jaspan, Heather; Toellner, Kai Michael; Waisman, Ari; Quesniaux, Valerie; Ryffel, Bernhard; Cunningham, Adam F.; Dewals, Benjamin G.; Brombacher, Frank; Horsnell, William G.C.
In: Science Advances, Vol. 5, No. 5, eaav3058, 29.05.2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
AU - Darby, Matthew G.
AU - Chetty, Alisha
AU - Mrjden, Dunja
AU - Rolot, Marion
AU - Smith, Katherine
AU - MacKowiak, Claire
AU - Sedda, Delphine
AU - Nyangahu, Donald
AU - Jaspan, Heather
AU - Toellner, Kai Michael
AU - Waisman, Ari
AU - Quesniaux, Valerie
AU - Ryffel, Bernhard
AU - Cunningham, Adam F.
AU - Dewals, Benjamin G.
AU - Brombacher, Frank
AU - Horsnell, William G.C.
PY - 2019/5/29
Y1 - 2019/5/29
N2 - Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4Rα -/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.
AB - Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4Rα -/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=85066339724&partnerID=8YFLogxK
U2 - 10.1126/sciadv.aav3058
DO - 10.1126/sciadv.aav3058
M3 - Article
C2 - 31236458
AN - SCOPUS:85066339724
VL - 5
JO - Science Advances
JF - Science Advances
SN - 2375-2548
IS - 5
M1 - eaav3058
ER -