Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Research output: Contribution to journalArticlepeer-review

Standard

Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. / Darby, Matthew G.; Chetty, Alisha; Mrjden, Dunja; Rolot, Marion; Smith, Katherine; MacKowiak, Claire; Sedda, Delphine; Nyangahu, Donald; Jaspan, Heather; Toellner, Kai Michael; Waisman, Ari; Quesniaux, Valerie; Ryffel, Bernhard; Cunningham, Adam F.; Dewals, Benjamin G.; Brombacher, Frank; Horsnell, William G.C.

In: Science Advances, Vol. 5, No. 5, eaav3058, 29.05.2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Darby, MG, Chetty, A, Mrjden, D, Rolot, M, Smith, K, MacKowiak, C, Sedda, D, Nyangahu, D, Jaspan, H, Toellner, KM, Waisman, A, Quesniaux, V, Ryffel, B, Cunningham, AF, Dewals, BG, Brombacher, F & Horsnell, WGC 2019, 'Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring', Science Advances, vol. 5, no. 5, eaav3058. https://doi.org/10.1126/sciadv.aav3058

APA

Darby, M. G., Chetty, A., Mrjden, D., Rolot, M., Smith, K., MacKowiak, C., Sedda, D., Nyangahu, D., Jaspan, H., Toellner, K. M., Waisman, A., Quesniaux, V., Ryffel, B., Cunningham, A. F., Dewals, B. G., Brombacher, F., & Horsnell, W. G. C. (2019). Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances, 5(5), [eaav3058]. https://doi.org/10.1126/sciadv.aav3058

Vancouver

Author

Darby, Matthew G. ; Chetty, Alisha ; Mrjden, Dunja ; Rolot, Marion ; Smith, Katherine ; MacKowiak, Claire ; Sedda, Delphine ; Nyangahu, Donald ; Jaspan, Heather ; Toellner, Kai Michael ; Waisman, Ari ; Quesniaux, Valerie ; Ryffel, Bernhard ; Cunningham, Adam F. ; Dewals, Benjamin G. ; Brombacher, Frank ; Horsnell, William G.C. / Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. In: Science Advances. 2019 ; Vol. 5, No. 5.

Bibtex

@article{a7f504b3b2974eea89d9672ee4b6ff27,
title = "Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring",
abstract = "Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4Rα -/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes. ",
author = "Darby, {Matthew G.} and Alisha Chetty and Dunja Mrjden and Marion Rolot and Katherine Smith and Claire MacKowiak and Delphine Sedda and Donald Nyangahu and Heather Jaspan and Toellner, {Kai Michael} and Ari Waisman and Valerie Quesniaux and Bernhard Ryffel and Cunningham, {Adam F.} and Dewals, {Benjamin G.} and Frank Brombacher and Horsnell, {William G.C.}",
year = "2019",
month = may,
day = "29",
doi = "10.1126/sciadv.aav3058",
language = "English",
volume = "5",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

AU - Darby, Matthew G.

AU - Chetty, Alisha

AU - Mrjden, Dunja

AU - Rolot, Marion

AU - Smith, Katherine

AU - MacKowiak, Claire

AU - Sedda, Delphine

AU - Nyangahu, Donald

AU - Jaspan, Heather

AU - Toellner, Kai Michael

AU - Waisman, Ari

AU - Quesniaux, Valerie

AU - Ryffel, Bernhard

AU - Cunningham, Adam F.

AU - Dewals, Benjamin G.

AU - Brombacher, Frank

AU - Horsnell, William G.C.

PY - 2019/5/29

Y1 - 2019/5/29

N2 - Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4Rα -/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.

AB - Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (TH2) impaired IL-4Rα -/- offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived TH2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=85066339724&partnerID=8YFLogxK

U2 - 10.1126/sciadv.aav3058

DO - 10.1126/sciadv.aav3058

M3 - Article

C2 - 31236458

AN - SCOPUS:85066339724

VL - 5

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 5

M1 - eaav3058

ER -