Preclinical development and first-in-human study of ATX-MS-1467 for immunotherapy of MS

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Authors

  • Heather B Streeter
  • Rachel Rigden
  • Keith F Martin
  • Neil J Scolding
  • David Wraith

Colleges, School and Institutes

Abstract

OBJECTIVE: The study was designed to test the efficacy of ATX-MS-1467 in a relevant preclinical model and to assess its safety for the treatment of patients with secondary progressive multiple sclerosis (SPMS).

METHODS: ATX-MS-1467 was tested for its ability to suppress experimental autoimmune encephalomyelitis (EAE) in the (Ob x DR2)F1 mouse both before and after disease onset. Safety was assessed by clinical assessment, MRI analysis, and the measurement of immune responses to self- and nonself-antigens in patients with SPMS.

RESULTS: ATX-MS-1467 displayed a dose-dependent inhibition of EAE and was more effective than glatiramer acetate in the treatment of ongoing disease in humanized mice. A phase 1 open-label dose-escalating study demonstrated that ATX-MS-1467 was safe and well-tolerated in a group of 6 patients with SPMS, up to a dose of 800 µg.

CONCLUSIONS: The results of this study support further development of ATX-MS-1467 in a clinical trial powered to investigate the immunologic and clinical benefits of treatment in relapsing-remitting MS.

CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that ATX-MS-1467 is safe and tolerated in a group of 6 patients with SPMS.

Details

Original languageEnglish
Article numbere93
Number of pages9
JournalNeurology: Neuroimmunology and NeuroInflammation
Volume2
Issue number3
Early online date12 Mar 2015
Publication statusPublished - Jun 2015

Keywords

  • Journal Article