Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Research output: Contribution to journalArticlepeer-review

Authors

  • Nicolas P.E. Barry
  • Anaïs Pitto-Barry
  • Johanna Tran
  • Joan J. Soldevila-Barreda
  • Ian Hands-Portman
  • Corinne J. Smith
  • Nigel Kirby
  • Andrew P. Dove
  • Rachel K. O'Reilly
  • Peter J. Sadler

Colleges, School and Institutes

External organisations

  • Warwick University
  • Australian Synchrotron

Abstract

We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells. This journal is

Details

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalFaraday Discussions
Volume175
Early online date1 Oct 2014
Publication statusPublished - 8 Dec 2014

ASJC Scopus subject areas