Post-transcriptional regulation of pro-inflammatory gene expression

Research output: Contribution to journalComment/debate

Colleges, School and Institutes

External organisations

  • St Mark's NHS Trust

Abstract

The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is illustrated by the clinical benefits of TNFα blockade. Post-transcriptional regulation (the control of mRNA stability and translation) appears to play a critical role in the regulation of TNFα expression by mitogen activated protein kinase signal transduction pathways and by anti-inflammatory agents. The aim of this article is to review some recent advances in our understanding of these processes, and to speculate on mechanisms of regulation of TNFα and other pro-inflammatory genes.

Details

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalArthritis Research
Volume2
Issue number3
Publication statusPublished - 1 Dec 2000

Keywords

  • Adenosine/uridine-rich element, Dexamethasone, Inflammation, MRNA stability, Translation, Tumour necrosis factor α

ASJC Scopus subject areas