Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38

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Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. / Clark, Andrew R.; Dean, Jonathan L.E.; Saklatvala, Jeremy.

In: FEBS Letters, Vol. 546, No. 1, 03.07.2003, p. 37-44.

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Clark, Andrew R. ; Dean, Jonathan L.E. ; Saklatvala, Jeremy. / Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. In: FEBS Letters. 2003 ; Vol. 546, No. 1. pp. 37-44.

Bibtex

@article{cc64bc012d134bcfaaf260f1701fd5b6,
title = "Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38",
abstract = "The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine synthesis. In almost a decade since this discovery, a great deal has been learned about the role of the p38 pathway in the post-transcriptional regulation of pro-inflammatory gene expression. However, important questions remain to be answered concerning the specificity and mechanism or mechanisms of action of p38. This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38.",
keywords = "Adenosine/uridine rich element, Inflammation, MAPK p38, MAPKAPK-2, mRNA stability, Translation",
author = "Clark, {Andrew R.} and Dean, {Jonathan L.E.} and Jeremy Saklatvala",
year = "2003",
month = jul,
day = "3",
doi = "10.1016/S0014-5793(03)00439-3",
language = "English",
volume = "546",
pages = "37--44",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38

AU - Clark, Andrew R.

AU - Dean, Jonathan L.E.

AU - Saklatvala, Jeremy

PY - 2003/7/3

Y1 - 2003/7/3

N2 - The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine synthesis. In almost a decade since this discovery, a great deal has been learned about the role of the p38 pathway in the post-transcriptional regulation of pro-inflammatory gene expression. However, important questions remain to be answered concerning the specificity and mechanism or mechanisms of action of p38. This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38.

AB - The mitogen-activated protein kinase p38 pathway was originally identified as a signalling cascade activated by pro-inflammatory stimuli and cellular stresses, and playing a critical role in the translational regulation of pro-inflammatory cytokine synthesis. In almost a decade since this discovery, a great deal has been learned about the role of the p38 pathway in the post-transcriptional regulation of pro-inflammatory gene expression. However, important questions remain to be answered concerning the specificity and mechanism or mechanisms of action of p38. This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38.

KW - Adenosine/uridine rich element

KW - Inflammation

KW - MAPK p38

KW - MAPKAPK-2

KW - mRNA stability

KW - Translation

UR - http://www.scopus.com/inward/record.url?scp=0038538477&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(03)00439-3

DO - 10.1016/S0014-5793(03)00439-3

M3 - Short survey

C2 - 12829234

AN - SCOPUS:0038538477

VL - 546

SP - 37

EP - 44

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -