Abstract
Polymers with a thermally triggered phase transition are important in the design of materials for biological applications, where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tunable thermal response, end-group reactive sites, low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile new poly(oligo(ethylene glycol) vinyl acetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end-group, and moreover show that this class of polymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently.
Original language | English |
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Pages (from-to) | 9178-9182 |
Number of pages | 5 |
Journal | Angewandte Chemie (International Edition) |
Volume | 56 |
Issue number | 31 |
Early online date | 30 Jun 2017 |
DOIs | |
Publication status | Published - 24 Jul 2017 |
Keywords
- biocompatibility
- copolymerization
- organocatalysis
- polymerization
- radical reactions