Poly(oligo(ethylene glycol) vinyl acetate)s: a versatile class of thermoresponsive and biocompatible polymers
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
External organisations
- Institute of Advanced Study, Millburn House, Millburn House Hill Road, The University of Warwick, Science Park, Coventry, CV4 8UW, UK.
- Department of Chemistry, The University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
Abstract
Polymers with a thermally triggered phase transition are important in the design of materials for biological applications, where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tunable thermal response, end-group reactive sites, low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile new poly(oligo(ethylene glycol) vinyl acetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end-group, and moreover show that this class of polymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently.
Details
Original language | English |
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Pages (from-to) | 9178-9182 |
Number of pages | 5 |
Journal | Angewandte Chemie (International Edition) |
Volume | 56 |
Issue number | 31 |
Early online date | 30 Jun 2017 |
Publication status | Published - 24 Jul 2017 |
Keywords
- biocompatibility, copolymerization, organocatalysis, polymerization, radical reactions