Poly(oligo(ethylene glycol) vinyl acetate)s: a versatile class of thermoresponsive and biocompatible polymers
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- Institute of Advanced Study, Millburn House, Millburn House Hill Road, The University of Warwick, Science Park, Coventry, CV4 8UW, UK.
- Department of Chemistry, The University of Warwick , Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.
Polymers with a thermally triggered phase transition are important in the design of materials for biological applications, where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tunable thermal response, end-group reactive sites, low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile new poly(oligo(ethylene glycol) vinyl acetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end-group, and moreover show that this class of polymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently.
|Number of pages||5|
|Journal||Angewandte Chemie (International Edition)|
|Early online date||30 Jun 2017|
|Publication status||Published - 24 Jul 2017|
- biocompatibility, copolymerization, organocatalysis, polymerization, radical reactions