Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification

Research output: Contribution to journalArticlepeer-review


  • Daniel N. Crisan
  • Oliver Creese
  • Ranadeb Ball
  • Jose Luis Brioso
  • Ben Martyn
  • Javier Montenegro

Colleges, School and Institutes

External organisations

  • University of Birmingham, Birmingham, B15 2TT, UK


Here we present the synthesis and post-polymerisation modification of poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: poly(acryloyl hydrazide) was prepared from commercially available starting materials in a three step synthesis on a large scale, in good yields and high purity. Our synthetic approach included the synthesis of a Boc-protected acryloyl hydrazide, the preparation of polymers via RAFT polymerisation and the deprotection of the corresponding Boc-protected poly(acryloyl hydrazide). Post-polymerisation modification of poly(acryloyl hydrazide) was then demonstrated using a range of conditions for both hydrophilic and hydrophobic aldehydes. These experiments demonstrate the potential of poly(acryloyl hydrazide) as a scaffold in the synthesis of functional polymers, in particular those applications where in situ screening of the activity of the functionalised polymers may be required (e.g. biological applications).


Original languageEnglish
Pages (from-to)4576-4584
JournalPolymer Chemistry
Issue number31
Early online date3 Jul 2017
Publication statusPublished - 20 Aug 2017