Abstract
Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.
Original language | English |
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Pages (from-to) | 1501-3 |
Number of pages | 3 |
Journal | Infection and Immunity |
Volume | 62 |
Issue number | 4 |
Publication status | Published - Apr 1994 |
Keywords
- Bacterial Proteins
- Cell Line
- Cytotoxins
- Humans
- Interleukin-1
- Lipopolysaccharides
- Monocytes
- Streptolysins
- Tumor Necrosis Factor-alpha