Platelet response heterogeneity in thrombus formation

Research output: Contribution to journalReview article

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Platelet response heterogeneity in thrombus formation. / Munnix, ICA; Cosemans, JMEM; Auger, Jocelyn; Heemskerk, JWM.

In: Thrombosis and Haemostasis, Vol. 102, No. 6, 01.12.2009, p. 1149-1156.

Research output: Contribution to journalReview article

Harvard

Munnix, ICA, Cosemans, JMEM, Auger, J & Heemskerk, JWM 2009, 'Platelet response heterogeneity in thrombus formation', Thrombosis and Haemostasis, vol. 102, no. 6, pp. 1149-1156. https://doi.org/10.1160/TH09-05-0289

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Vancouver

Author

Munnix, ICA ; Cosemans, JMEM ; Auger, Jocelyn ; Heemskerk, JWM. / Platelet response heterogeneity in thrombus formation. In: Thrombosis and Haemostasis. 2009 ; Vol. 102, No. 6. pp. 1149-1156.

Bibtex

@article{dec68fc3009c4732aaaede30fbcd5612,
title = "Platelet response heterogeneity in thrombus formation",
abstract = "Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in a thrombus adhere to different substrates, and sense specific (ant)agonists and rheological conditions. Contraction of platelets and interaction with fibrin and other blood cells cause further response variation. On the other hand, response heterogeneity can also be due to intrinsic differences between platelets in age and in receptor and signalling proteins. As a result, at least three subpopulations of platelets are formed in a thrombus: aggregating platelets with (reversible) integrin activation, procoagulant (coated) platelets exposing phosphatidylserine and binding coagulation factors, and contracting platelets with cell-cell contacts. This recognition of thrombus heterogeneity has implications for the use and development of antiplatelet medication.",
keywords = "platelets, Aggregation, heterogeneity, thrombus formation, coagulation",
author = "ICA Munnix and JMEM Cosemans and Jocelyn Auger and JWM Heemskerk",
year = "2009",
month = dec,
day = "1",
doi = "10.1160/TH09-05-0289",
language = "English",
volume = "102",
pages = "1149--1156",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer",
number = "6",

}

RIS

TY - JOUR

T1 - Platelet response heterogeneity in thrombus formation

AU - Munnix, ICA

AU - Cosemans, JMEM

AU - Auger, Jocelyn

AU - Heemskerk, JWM

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in a thrombus adhere to different substrates, and sense specific (ant)agonists and rheological conditions. Contraction of platelets and interaction with fibrin and other blood cells cause further response variation. On the other hand, response heterogeneity can also be due to intrinsic differences between platelets in age and in receptor and signalling proteins. As a result, at least three subpopulations of platelets are formed in a thrombus: aggregating platelets with (reversible) integrin activation, procoagulant (coated) platelets exposing phosphatidylserine and binding coagulation factors, and contracting platelets with cell-cell contacts. This recognition of thrombus heterogeneity has implications for the use and development of antiplatelet medication.

AB - Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in a thrombus adhere to different substrates, and sense specific (ant)agonists and rheological conditions. Contraction of platelets and interaction with fibrin and other blood cells cause further response variation. On the other hand, response heterogeneity can also be due to intrinsic differences between platelets in age and in receptor and signalling proteins. As a result, at least three subpopulations of platelets are formed in a thrombus: aggregating platelets with (reversible) integrin activation, procoagulant (coated) platelets exposing phosphatidylserine and binding coagulation factors, and contracting platelets with cell-cell contacts. This recognition of thrombus heterogeneity has implications for the use and development of antiplatelet medication.

KW - platelets

KW - Aggregation

KW - heterogeneity

KW - thrombus formation

KW - coagulation

U2 - 10.1160/TH09-05-0289

DO - 10.1160/TH09-05-0289

M3 - Review article

C2 - 19967145

VL - 102

SP - 1149

EP - 1156

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 6

ER -