Platelet aggregation induced by polystyrene and platinum nanoparticles is dependent on surface area

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Nanoparticles are key components underlying recent technological advances in various industrial and medical fields, and thus understanding their mode of interaction with biological systems is essential. However, while several nanoparticle systems have been shown to interact with blood platelets, many questions remain concerning the mechanisms of platelet activation and the role that the physicochemical properties of nanoparticles play in inducing platelet aggregation. Here, using negatively charged polystyrene nanoparticles with sizes of 25, 50, 119, 151, 201 nm and negatively charged platinum nanoparticles with sizes of 7 and 73 nm, we show that it is not the size of the nanoparticles but rather the nanoparticle surface area that is critical in mediating the effects on platelet activation. The nanoparticles stimulate platelet aggregation through passive (agglutination) and activation of integrin IIb3 through a pathway regulated by Src and Syk tyrosine kinase.

Details

Original languageEnglish
Pages (from-to)37789-37794
Number of pages6
JournalRSC Advances
Volume8
Issue number66
Early online date12 Nov 2018
Publication statusE-pub ahead of print - 12 Nov 2018