Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

S Massberg; K Schurzinger; M Lorenz; I Konrad; C Schulz; N Plesnila; E Kennerknecht; M Rudelius; S Sauer; S Braun; E Kremmer; NR Emambokus; Jonathan Frampton; M Gawaz

doi:10.1161/CIRCULATIONAHA.105.539221

Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

S Massberg, K Schurzinger, M Lorenz, I Konrad, C Schulz, N Plesnila, E Kennerknecht, M Rudelius, S Sauer, S Braun, E Kremmer, NR Emambokus, Jonathan Frampton, M Gawaz

Research output: Contribution to journal › Article

125 Citations (Scopus)

Abstract

BACKGROUND: The platelet glycoprotein (GP) IIb/IIIa integrin binds to fibrinogen and thereby mediates platelet aggregation. Here, we addressed the role of GP IIb for platelet adhesion and determined the relevance of platelet GP IIb for the processes of atherosclerosis and cerebral ischemia-reperfusion (I/R) injury. METHODS AND RESULTS: GP IIb(-/-) mice were generated and bred with ApoE(-/-) animals to create GP IIb(-/-)ApoE(-/-) mice. Platelet adhesion to the mechanically injured or atherosclerotic vessel wall was monitored by in vivo video fluorescence microscopy. In the presence of GP IIb, vascular injury and early atherosclerosis induced platelet adhesion in the carotid artery (CA). In contrast, platelet adhesion was significantly reduced in the absence of GP IIb integrin (P

Original language	English
Pages (from-to)	1180-8
Number of pages	9
Journal	Circulation
Volume	112
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.105.539221
Publication status	Published - 23 Aug 2005

Keywords

stroke
cerebral ischemia
endothelium
platelets
cerebral infarction

Access to Document

10.1161/CIRCULATIONAHA.105.539221

Cite this

Massberg, S., Schurzinger, K., Lorenz, M., Konrad, I., Schulz, C., Plesnila, N., Kennerknecht, E., Rudelius, M., Sauer, S., Braun, S., Kremmer, E., Emambokus, NR., Frampton, J., & Gawaz, M. (2005). Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb. Circulation, 112, 1180-8. https://doi.org/10.1161/CIRCULATIONAHA.105.539221

@article{93903cce29524e35872baecd5874f332,

title = "Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb",

abstract = "BACKGROUND: The platelet glycoprotein (GP) IIb/IIIa integrin binds to fibrinogen and thereby mediates platelet aggregation. Here, we addressed the role of GP IIb for platelet adhesion and determined the relevance of platelet GP IIb for the processes of atherosclerosis and cerebral ischemia-reperfusion (I/R) injury. METHODS AND RESULTS: GP IIb(-/-) mice were generated and bred with ApoE(-/-) animals to create GP IIb(-/-)ApoE(-/-) mice. Platelet adhesion to the mechanically injured or atherosclerotic vessel wall was monitored by in vivo video fluorescence microscopy. In the presence of GP IIb, vascular injury and early atherosclerosis induced platelet adhesion in the carotid artery (CA). In contrast, platelet adhesion was significantly reduced in the absence of GP IIb integrin (P",

keywords = "stroke, cerebral ischemia, endothelium, platelets, cerebral infarction",

author = "S Massberg and K Schurzinger and M Lorenz and I Konrad and C Schulz and N Plesnila and E Kennerknecht and M Rudelius and S Sauer and S Braun and E Kremmer and NR Emambokus and Jonathan Frampton and M Gawaz",

year = "2005",

month = aug,

day = "23",

doi = "10.1161/CIRCULATIONAHA.105.539221",

language = "English",

volume = "112",

pages = "1180--8",

journal = "Circulation",

issn = "1524-4539",

publisher = "American Heart Association",

}

Massberg, S, Schurzinger, K, Lorenz, M, Konrad, I, Schulz, C, Plesnila, N, Kennerknecht, E, Rudelius, M, Sauer, S, Braun, S, Kremmer, E, Emambokus, NR, Frampton, J & Gawaz, M 2005, 'Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb', Circulation, vol. 112, pp. 1180-8. https://doi.org/10.1161/CIRCULATIONAHA.105.539221

TY - JOUR

T1 - Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

AU - Massberg, S

AU - Schurzinger, K

AU - Lorenz, M

AU - Konrad, I

AU - Schulz, C

AU - Plesnila, N

AU - Kennerknecht, E

AU - Rudelius, M

AU - Sauer, S

AU - Braun, S

AU - Kremmer, E

AU - Emambokus, NR

AU - Frampton, Jonathan

AU - Gawaz, M

PY - 2005/8/23

Y1 - 2005/8/23

N2 - BACKGROUND: The platelet glycoprotein (GP) IIb/IIIa integrin binds to fibrinogen and thereby mediates platelet aggregation. Here, we addressed the role of GP IIb for platelet adhesion and determined the relevance of platelet GP IIb for the processes of atherosclerosis and cerebral ischemia-reperfusion (I/R) injury. METHODS AND RESULTS: GP IIb(-/-) mice were generated and bred with ApoE(-/-) animals to create GP IIb(-/-)ApoE(-/-) mice. Platelet adhesion to the mechanically injured or atherosclerotic vessel wall was monitored by in vivo video fluorescence microscopy. In the presence of GP IIb, vascular injury and early atherosclerosis induced platelet adhesion in the carotid artery (CA). In contrast, platelet adhesion was significantly reduced in the absence of GP IIb integrin (P

AB - BACKGROUND: The platelet glycoprotein (GP) IIb/IIIa integrin binds to fibrinogen and thereby mediates platelet aggregation. Here, we addressed the role of GP IIb for platelet adhesion and determined the relevance of platelet GP IIb for the processes of atherosclerosis and cerebral ischemia-reperfusion (I/R) injury. METHODS AND RESULTS: GP IIb(-/-) mice were generated and bred with ApoE(-/-) animals to create GP IIb(-/-)ApoE(-/-) mice. Platelet adhesion to the mechanically injured or atherosclerotic vessel wall was monitored by in vivo video fluorescence microscopy. In the presence of GP IIb, vascular injury and early atherosclerosis induced platelet adhesion in the carotid artery (CA). In contrast, platelet adhesion was significantly reduced in the absence of GP IIb integrin (P

KW - stroke

KW - cerebral ischemia

KW - endothelium

KW - platelets

KW - cerebral infarction

UR - http://www.scopus.com/inward/record.url?scp=24044440435&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.105.539221

DO - 10.1161/CIRCULATIONAHA.105.539221

M3 - Article

C2 - 16103235

SN - 1524-4539

VL - 112

SP - 1180

EP - 1188

JO - Circulation

JF - Circulation

ER -

Platelet Adhesion Via Glycoprotein IIb Integrin Is Critical for Atheroprogression and Focal Cerebral Ischemia. An In Vivo Study in Mice Lacking Glycoprotein IIb

Abstract

Keywords

Access to Document

Fingerprint

Cite this