TY - JOUR
T1 - Plasma vacular endothelial growth factor, soluble VEGF receptor flt-1 and von Willebrand factor in glaucoma
AU - Lip, Peck-Lin
AU - Felmeden, Dirk
AU - Blann, Andrew
AU - Matheou, N
AU - Thakur, S
AU - Cunliffe, Ian
AU - Lip, Gregory
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Aim: To investigate plasma indices of vascular permeability (vascular endothelial growth factor, VEGF-also an index of angiogenesis, as well as the soluble receptor for VEGF, sFlt-1) and endothelial damage/dysfunction (von Willebrand factor, vWf) in glaucoma.
Methods: Citrated plasma was assayed for VEGF, sFlt-1, and vWf (all ELISA) in a cross sectional study of 50 patients (20 male; mean age 63.9 years, SD 10.5) with glaucoma: 26 had normal tension glaucoma (NTG) and 24 had primary open angle glaucoma (POAG), who were compared with 26 healthy controls (mean age 73.4 years, SD 9.2).
Results: Median (interquartile range, IQR) levels of VEGF were significantly elevated in patients with NTG and POAG compared to healthy controls (Kruskal-Wallis test, p
AB - Aim: To investigate plasma indices of vascular permeability (vascular endothelial growth factor, VEGF-also an index of angiogenesis, as well as the soluble receptor for VEGF, sFlt-1) and endothelial damage/dysfunction (von Willebrand factor, vWf) in glaucoma.
Methods: Citrated plasma was assayed for VEGF, sFlt-1, and vWf (all ELISA) in a cross sectional study of 50 patients (20 male; mean age 63.9 years, SD 10.5) with glaucoma: 26 had normal tension glaucoma (NTG) and 24 had primary open angle glaucoma (POAG), who were compared with 26 healthy controls (mean age 73.4 years, SD 9.2).
Results: Median (interquartile range, IQR) levels of VEGF were significantly elevated in patients with NTG and POAG compared to healthy controls (Kruskal-Wallis test, p
UR - http://www.scopus.com/inward/record.url?scp=0036828280&partnerID=8YFLogxK
U2 - 10.1136/bjo.86.11.1299
DO - 10.1136/bjo.86.11.1299
M3 - Article
C2 - 12386093
SN - 1468-2079
VL - 86
SP - 1299
EP - 1302
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 11
ER -